Renée Maas

380 Chapter 13 120. Funk, F. et al. Phospholamban pentamerization increases sensitivity and dynamic range of cardiac relaxation. Cardiovasc. Res. 119, (2023). 121. Zhihao, L. et al. SERCA2a: a key protein in the Ca2+ cycle of the heart failure. Heart Fail. Rev. 25, (2020). 122. Nishiyama, T., Bassel-Duby, R. & Olson, E. N. Toward CRISPR Therapies for Cardiomyopathies. Circulation 144, 1525–1527 (2021). 123. Yeates, L. et al. Decision-making and experiences of preimplantation genetic diagnosis in inherited heart diseases: a qualitative study. Eur. J. Hum. Genet. 30, 187–193 (2021). 124. Heinig, M. et al. Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy. Genome Biol. 18, (2017). 125. Burkart, V. et al. Transcriptional bursts and heterogeneity among cardiomyocytes in hypertrophic cardiomyopathy. Front. Cardiovasc. Med. 0, (2022). 126. Yan, H., Yuan, W., Velculescu, V. E., Vogelstein, B. & Kinzler, K. W. Allelic variation in human gene expression. Science 297, 1143 (2002). 127. He, L., Loika, Y. & Kulminski, A. M. Allele-specific analysis reveals exon- and cell-type-specific regulatory effects of Alzheimer’s disease-associated genetic variants. Transl. Psychiatry 12, (2022). 128. Matsa, E. et al. Transcriptome profiling of patient-specific human iPSC-cardiomyocytes predicts individual drug safety and efficacy responses in vitro. Cell Stem Cell 19, 311 (2016). 129. Dekkers, J. F. et al. A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nat. Med. 19, 939–945 (2013). 130. HUB Organoid model development. HUB Organoids https://www.huborganoids.nl/biobank/ (2022). 131. Cahill, T. J., Ashrafian, H. & Watkins, H. Genetic Cardiomyopathies Causing Heart Failure. Circ. Res. (2013) doi:10.1161/CIRCRESAHA.113.300282. 132. Jacoby, D. & McKenna, W. J. Genetics of inherited cardiomyopathy. Eur. Heart J. 33, 296 (2012). 133. Richard, P., Villard, E., Charron, P. & Isnard, R. The Genetic Bases of Cardiomyopathies. Journal of the American College of Cardiology vol. 48 A79–A89 Preprint at https://doi.org/10.1016/j.jacc.2006.09.014 (2006). 134. Albakri, A. Inherited cardiomyopathies: A review and pooled analysis of pathophysiology, diagnosis and clinical management. Internal Medicine and Care vol. 3 Preprint at https://doi.org/10.15761/imc.1000135 (2019). 135. Bertero, E., Heusch, G., Münzel, T. & Maack, C. A pathophysiological compass to personalize antianginal drug treatment. Nat. Rev. Cardiol. 18, (2021).

RkJQdWJsaXNoZXIy MTk4NDMw