TABLE OF CONTENTS Chapter 1 General Introduction and Thesis Outline 11 Part I - From Heart Development Towards Optimal Cardiac in Vitro Models Chapter 2 Harnessing Developmental Cues for Cardiomyocyte Production Development 2023. 27 Chapter 3 Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes Cell Stem Cell 2020. 55 Chapter 4 Massive Expansion and Cryopreservation of Functional Human Induced Pluripotent Stem cell-Derived Cardiomyocytes Cell STAR protocols 2021. 87 Chapter 5 Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes Journal of Cardiovascular Development and Disease 2022. 107 Chapter 6 Metabolic Maturation Increases Susceptibility to Hypoxia-Induced Damage in Human iPSC-Derived Cardiomyocytes Stem Cells Translational Medicine 2022. 125 Part II - Modelling the Phospholamban R14del Mutation using Patient-Specific hiPSC-CMs Chapter 7 Phospholamban p.Arg14del Cardiomyopathy: a Systematic Summary of the Pathophysiological Mechanisms. Manuscript submitted to Circulation Research. 149 Chapter 8 Transcriptional Regulation Profiling Reveals PPARA-mediated Fatty Acid Oxidation as a Novel Therapeutic Target in Phospholamban R14del Cardiomyopathy Preprint online (Research Square) 2022. 199 Chapter 9 Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy Circulation 2021. 239
RkJQdWJsaXNoZXIy MTk4NDMw