Renée Maas

82 Chapter 3 19. Janda, C.Y., Dang, L.T., You, C., Chang, J., de Lau, W., Zhong, Z.A., Yan, K.S., Marecic, O.,Siepe, D., Li, X., et al. (2017). Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling. Nature 545, 234–237. 20. Kerkela, R., Kockeritz, L., MacAulay, K., Zhou, J., Doble, B.W., Beahm, C., Greytak, S., Woulfe, K., Trivedi, C.M., Woodgett, J.R., et al. (2008). Deletion of GSK-3β in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest 118, 3609–3618. 21. Kim, J.-H., and Asthagiri, A.R. (2011). Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation. J Cell Sci 124, 1280–1287. 22. Kim, N.-G., Koh, E., Chen, X., and Gumbiner, B.M. (2011). E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc. Natl. Acad. Sci. U.S.A. 108, 11930–11935. 23. Li, J., Gao, E., Vite, A., Yi, R., Gomez, L., Goossens, S., van Roy, F., and Radice, G.L. (2015). Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity. Circ. Res. 116, 70–79. 24. Lian, X., Hsiao, C., Wilson, G., Zhu, K., Hazeltine, L.B., Azarin, S.M., Raval, K.K., Zhang, J., Kamp, T.J., and Palecek, S.P. (2012). Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc. Natl. Acad. Sci. U.S.A. 109, E1848-1857. 25. Lian, X., Zhang, J., Azarin, S.M., Zhu, K., Hazeltine, L.B., Bao, X., Hsiao, C., Kamp, T.J., and Palecek, S.P. (2013). Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nat Protoc 8, 162–175. 26. Lin, Z., Zhou, P., von Gise, A., Gu, F., Ma, Q., Chen, J., Guo, H., van Gorp, P.R.R., Wang, D.-Z., and Pu, W.T. (2015). Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ. Res. 116, 35–45. 27. Lindsley, C.W., Barnett, S.F., Yaroschak, M., Bilodeau, M.T., and Layton, M.E. (2007). Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors. Curr Top Med Chem 7, 1349–1363. 28. Liu, P., Begley, M., Michowski, W., Inuzuka, H., Ginzberg, M., Gao, D., Tsou, P., Gan, W.,Papa, A., Kim, B.M., et al. (2014). Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature 508, 541–545. 29. Liu, X., Yagi, H., Saeed, S., Bais, A.S., Gabriel, G.C., Chen, Z., Peterson, K.A., Li, Y., Schwartz, M.C., Reynolds, W.T., et al. (2017). The complex genetics of hypoplastic left heart syndrome. Nat. Genet. 49, 1152–1159. 30. Liu, Y.-W., Chen, B., Yang, X., Fugate, J.A., Kalucki, F.A., Futakuchi-Tsuchida, A., Couture, L.,Vogel, K.W., Astley, C.A., Baldessari, A., et al. (2018). Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates. Nat. Biotechnol. 36, 597–605. 31. Matsa, E., Burridge, P.W., Yu, K.-H., Ahrens, J.H., Termglinchan, V., Wu, H., Liu, C., Shukla, P., Sayed, N., Churko, J.M., et al. (2016). Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell 19, 311–325. 32. Mills, R.J., Titmarsh, D.M., Koenig, X., Parker, B.L., Ryall, J.G., Quaife-Ryan, G.A., Voges, H.K.,Hodson, M.P., Ferguson, C., Drowley, L., et al. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proc Natl Acad Sci USA 114, E8372–E8381. 33. Mills, R.J., Parker, B.L., Quaife-Ryan, G.A., Voges, H.K., Needham, E.J., Bornot, A., Ding, M., Andersson, H., Polla, M., Elliott, D.A., et al. (2019). Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway. Cell Stem Cell 24, 895-907.e6. 34. Mirzaa, G., Parry, D.A., Fry, A.E., Giamanco, K.A., Schwartzentruber, J., Vanstone, M., Logan, C.V., Roberts, N., Johnson, C.A., Singh, S., et al. (2014). De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. Nat. Genet. 46, 510–515. 35. Nusse, R., and Clevers, H. (2017). Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell 169, 985–999. 36. Ogle, B.M., Bursac, N., Domian, I., Huang, N.F., Menasché, P., Murry, C.E., Pruitt, B., Radisic, M., Wu, J.C., Wu, S.M., et al. (2016). Distilling complexity to advance cardiac tissue engineering. Sci Transl Med 8, 342ps13. 37. Puliafito, A., Hufnagel, L., Neveu, P., Streichan, S., Sigal, A., Fygenson, D.K., and Shraiman, B.I. (2012). Collective and single cell behavior in epithelial contact inhibition. PNAS 109, 739–744.

RkJQdWJsaXNoZXIy MTk4NDMw