83 Massive Expansion of Functional Human iPSC-derived Cardiomyocytes 3 38. Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., and Brivanlou, A.H. (2004). Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3specific inhibitor. Nat. Med. 10, 55–63. 39. Senyo, S.E., Lee, R.T., and Kühn, B. (2014). Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation. Stem Cell Res 13, 532–541. 40. Sharma, A., Zhang, Y., Buikema, J.W., Serpooshan, V., Chirikian, O., Kosaric, N., Churko, J.M., Dzilic, E., Shieh, A., Burridge, P.W., et al. (2018). Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation. Scientific Reports 8, 6618. 41. Sharma, P., Abbasi, C., Lazic, S., Teng, A.C.T., Wang, D., Dubois, N., Ignatchenko, V., Wong, V., Liu, J., Araki, T., et al. (2015). Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nature Communications 6, 8391. 42. Sherr, C.J., Beach, D., and Shapiro, G.I. (2016). Targeting CDK4 and CDK6: From Discovery to Therapy. Cancer Discov 6, 353–367. 43. Shiba, Y., Gomibuchi, T., Seto, T., Wada, Y., Ichimura, H., Tanaka, Y., Ogasawara, T., Okada, K., Shiba, N., Sakamoto, K., et al. (2016). Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts. Nature 538, 388–391. 44. Song, G., Ouyang, G., and Bao, S. (2005). The activation of Akt/PKB signaling pathway and cell survival. J. Cell. Mol. Med. 9, 59–71. 45. Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W.M., Hao, Y., Stoeckius, M., Smibert, P., and Satija, R. (2019). Comprehensive Integration of Single-Cell Data. Cell 177, 1888-1902.e21. 46. Sturzu, A.C., Rajarajan, K., Passer, D., Plonowska, K., Riley, A., Tan, T.C., Sharma, A., Xu, A.F., Engels, M.C., Feistritzer, R., et al. (2015). The Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss. Circulation 132, 109–121. 47. Titmarsh, D.M., Glass, N.R., Mills, R.J., Hidalgo, A., Wolvetang, E.J., Porrello, E.R., Hudson, J.E., and Cooper-White, J.J. (2016). Induction of Human iPSC-Derived Cardiomyocyte Proliferation Revealed by Combinatorial Screening in High Density Microbioreactor Arrays. Scientific Reports 6, 1–15. 48. Trosset, J.-Y., Dalvit, C., Knapp, S., Fasolini, M., Veronesi, M., Mantegani, S., Gianellini, L.M., Catana, C., Sundström, M., Stouten, P.F.W., et al. (2006). Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins 64, 60–67. 49. Tseng, A.-S., Engel, F.B., and Keating, M.T. (2006). The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes. Chemistry & Biology 13, 957–963. 50. Uosaki, H., Magadum, A., Seo, K., Fukushima, H., Takeuchi, A., Nakagawa, Y., Moyes, K.W., Narazaki, G., Kuwahara, K., Laflamme, M., et al. (2013). Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells. Circ Cardiovasc Genet 6, 624–633. 51. Uygur, A., and Lee, R.T. (2016). Mechanisms of Cardiac Regeneration. Dev Cell 36, 362–374. 52. Wu, S.M., Chien, K.R., and Mummery, C. (2008). Origins and fates of cardiovascular progenitor cells. Cell 132, 537–543. 53. Yan, K.S., Janda, C.Y., Chang, J., Zheng, G.X.Y., Larkin, K.A., Luca, V.C., Chia, L.A., Mah, A.T., Han, A., Terry, J.M., et al. (2017). Non-equivalence of Wnt and R-spondin ligands during Lgr5 + intestinal stem-cell self-renewal. Nature 545, 238–242. 54. Yin, X., Farin, H.F., van Es, J.H., Clevers, H., Langer, R., and Karp, J.M. (2014). Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nat. Methods 11, 106–112. 55. Zhang, Y., Cao, N., Huang, Y., Spencer, C.I., Fu, J.-D., Yu, C., Liu, K., Nie, B., Xu, T., Li, K., et al. (2016). Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. Cell Stem Cell 18, 368–381.
RkJQdWJsaXNoZXIy MTk4NDMw