Chapter 10 Generation of Human Induced Pluripotent Stem Cell (hiPSC) Lines Derived from Six Patients Carrying the Pathogenic PhospholambanR14del (PLN-R14del) Variant and Two non-carrier Family Members Manuscript in preparation. 263 Chapter 11 Generation, High Throughput Screening, and Biob anking of Human iPSC-Derived Cardiac Spheroids Journal of Visualized Experiments 2023. 277 Chapter 12 Modeling and Rescue of PLN-R14del Cardiomyopathy Phenotype in Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids Manuscript in preparation. 297 Part III - General Discussion and Summary Chapter 13 General Discussion - hiPSC-CMs Disease Modelling and Future Perspectives 347 Chapter 14 General Summary 383 Appendices Summary in Dutch 390 List of publications 395 Acknowledgements 401 About the author 409 UU PhD Portfolio 411
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