Renée Maas

Chapter 1 General Introduction and Thesis Outline	11
Chapter 2 Harnessing Developmental Cues for Cardiomyocyte Production	27
Chapter 3 Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes	55
Chapter 4 Massive Expansion and Cryopreservation of Functional Human Induced Pluripotent Stem cell-Derived Cardiomyocytes	87
Chapter 5 Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes	107
Chapter 6 Metabolic Maturation Increases Susceptibility to Hypoxia-Induced Damage in Human iPSC-Derived Cardiomyocytes	125
Chapter 7 Phospholamban p.Arg14del Cardiomyopathy: a Systematic Summary of the Pathophysiological Mechanisms	149
Chapter 8 Transcriptional Regulation Profiling Reveals PPARA-mediated Fatty Acid Oxidation as a Novel Therapeutic Target in Phospholamban R14del Cardiomyopathy	199
Chapter 9 Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy	239
Chapter 10 Generation of Human Induced Pluripotent Stem Cell (hiPSC) Lines Derived from Six Patients Carrying the Pathogenic Phospholamban R14del (PLN-R14del) Variant and Two non-carrier Family Members	263
Chapter 11 Generation, High Throughput Screening, and Biob anking of Human iPSC-Derived Cardiac Spheroids	277
Chapter 12 Modeling and Rescue of PLN-R14del Cardiomyopathy Phenotype in Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids	297
Chapter 13 General Discussion - hiPSC-CMs Disease Modelling and Future Perspectives	347
Chapter 14 General Summary	383
Summary in Dutch	390
List of publications	395
Acknowledgements	401
About the author	409
UU PhD Portfolio	411

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