31 2 Tuberculosis treatment and abnormal blood glucose. COVID-19 pandemic where we expect more screening for diabetes would be done since it is a high-risk factor for COVID-19-associated mortality. Finally, our review team have diverse expertise (infectious disease epidemiologists, biostatisticians, clinicians, public health specialists and non-communicable disease epidemiologists), which served as a useful resource to guide the review process. As a limitation, our review included relatively few articles as most studies in this field assessed glucose changes in known DM patients receiving treatment for TB. Since we did not extract records from all the databases, we may have missed some studies from the databases we did not search. For studies published during the COVID-19 pandemic, bias may likely have been introduced by elevated dysglycaemia from COVID-19 infections. But these are few and published in the early days of the pandemic. No risk of bias assessment was done to ascertain the methodological rigour of the included studies; therefore, recommendations cannot be provided based on the findings of this review. Nevertheless, we have been able to present findings from studies that describe glucose changes in non-DM patients receiving treatment for TB. Conclusion This scoping review aimed to identify and compile the available evidence on possible abnormalities in blood glucose during and after TB treatment. The studies indicated that dysglycaemia in patients receiving treatment for TB normalised after commencing anti-TB medication at the end of treatment, and a positive HIV status was not associated with glucose changes during TB treatment. There was no standardised method and time for testing or screening as the reviewed studies adopted different approaches. Further investigations on patient follow-up after TB treatment for possible signs of glucose changes that may result in high mortality and the impact of HIV on the association between DM and TB are required. This will enable definitive conclusions on the observed high mortality in persons with high glucose post-treatment and any effect of HIV on the association between DM and TB. Paper context Evidence of changes in blood glucose during tuberculosis treatment and the association with HIV is unclear. Our study shows that dysglycaemia identified at the onset of tuberculosis treatment is normalised at follow-up and end of treatment and patients with baseline dysglycaemia have poor outcomes post-treatment compared to normoglycaemic patients. HIV status was not associated with glucose changes during
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