José Manuel Horcas Nieto

114 Chapter 4 REFERENCES 1. van Zutphen T, Ciapaite J, Bloks VW, et al. Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. J Hepatol. 2016;65(6):1198-1208. doi:10.1016/j.jhep.2016.05.046 2. Hu G, Ling C, Chi L, et al. The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction. Nat Commun. 2022;13(1). doi:10.1038/ s41467-022-35317-y 3. Arvidsson Kvissberg ME, Hu G, Chi L, et al. Inhibition of mTOR improves malnutrition induced hepatic metabolic dysfunction. Sci Rep. 2022;12(1). doi:10.1038/s41598-02224428-7 4. Doherty JF, Golden MH, Brooks SE. Peroxisomes and the fatty liver of malnutrition: an hypothesis. Am J Clin Nuir. 1991;54:674-681. doi:10.1093/ajcn/54.4.674 5. Horcas-Nieto JM, Versloot CJ, Langelaar-Makkinje M, et al. Organoids as a model to study intestinal and liver dysfunction in severe malnutrition. Biochim Biophys Acta Mol Basis Dis. 2023;1869(3). doi:10.1016/j.bbadis.2022.166635 6. Liu C, Ji L, Hu J, et al. Functional amino acids and autophagy: Diverse signal transduction and application. Int J Mol Sci. 2021;22(21). doi:10.3390/ijms222111427 7. Glick D, Barth S, Macleod KF. Autophagy: Cellular and molecular mechanisms. Journal of Pathology. 2010;221(1):3-12. doi:10.1002/path.2697 8. Mizushima N. SnapShot: Organelle degradation. Mol Cell. 2022;82(8):1604-1604.e1. doi:10.1016/j.molcel.2022.03.015 9. Singh R, Cuervo AM. Autophagy in the cellular energetic balance. Cell Metab. 2011;13(5):495-504. doi:10.1016/j.cmet.2011.04.004 10. Briend A. Collaborating to Improve the Management of Acute Malnutrition Worldwide Kwashiorkor: Still an Enigma-the Search Must Go On.; 2014. www.cmamforum.org 11. World Health Organization Geneva MANAGEMENT OF SEVERE MALNUTRITION: A MANUAL FOR PHYSICIANS AND OTHER SENIOR HEALTH WORKERS. 12. Bandsma RHJ, Mendel M, Spoelstra MN, et al. Mechanisms Behind Decreased Endogenous Glucose Production in Malnourished Children. Pediatr Res. Published online 2010. doi:10.1203/PDR.0b013e3181f2b959 13. Wharton B. Hypoglycaemia in children with Kwashiorkor. The Lancet. 1967;295(7639):171-173. doi:10.1016/s0140-6736(70)90408-3 14. Badaloo A V, Forrester T, Reid M, Jahoor F. Lipid kinetic differences between children with kwashiorkor and those with marasmus. Am J Clin Nutr. Published online 2006. doi:10.1093/ajcn/83.6.1283 15. Badaloo A, Reid M, Soares D, Forrester T, Jahoor F. Relation between liver fat content and the rate of VLDL apolipoprotein B-100 synthesis in children with protein-energy malnutrition. Am J Clin Nutri. Published online 2005. doi:10.1093/ajcn/81.5.1126 16. di Giovanni V, Bourdon C, Wang DX, et al. Metabolomic changes in serum of children with different clinical diagnoses of malnutrition. Journal of Nutrition. 2016;146(12):24362444. doi:10.3945/jn.116.239145

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