148 Chapter 5 FUNDING This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 812968. ACKNOWLEDGEMENTS We would like to thank Prof. Ronald Wanders for his help and insights into peroxisomal biochemistry and Karen van Eunen for advice on the computational modeling. REFERENCES 1. De Duve, Christian. & Baudhuin, Pierre. Peroxisomes (Microbodies and Related Particles). Physiol Rev. 46, 323–357 (1966). 2. Wanders, R. J. A. & Waterham, H. R. Biochemistry of mammalian peroxisomes revisited. Annual Review of Biochemistry vol. 75 295–332 Preprint at https://doi.org/10.1146/ annurev.biochem.74.082803.133329 (2006). 3. Schrader, M., Costello, J., Godinho, L. F. & Islinger, M. Peroxisome-mitochondria interplay and disease. Journal of Inherited Metabolic Disease vol. 38 681–702 Preprint at https://doi.org/10.1007/s10545-015-9819-7 (2015). 4. Wanders, R. J. A., Baes, M., Ribeiro, D., Ferdinandusse, S. & Waterham, H. R. The physiological functions of human peroxisomes. Physiological Reviews vol. 103 957–1024 Preprint at https://doi.org/10.1152/physrev.00051.2021 (2023). 5. Violante, S. et al. Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4. FASEB Journal 33, 4355–4364 (2019). 6. Osmundsen, H., Neat, C. E. & Borrebaek, B. Fatty acid products of peroxisomal β-oxidation. J Bmhum vol. 12. 7. Neat, C. E., Thomassent, M. S. & Osmundsen, H. Effects of high-fat diets on hepatic fatty acid oxidation in the rat Isolation of rat liver peroxisomes by vertical-rotor centrifugation by using a self-generated, iso-osmotic, Percoli gradient. Biochem. J vol. 196 (1981). 8. Hiltunen, J. K., Karki, T., Hassinen, I. E. & Osmundsen, H. β-Oxidation of polyunsaturated fatty acids by rat liver peroxisomes. A role for 2,4-dienoyl-coenzyme A reductase in peroxisomal β-oxidation. Journal of Biological Chemistry 261, 16484–16493 (1986). 9. Hovik, R. & Osmundsen, H. Peroxisomal f-oxidation of long-chain fatty acids possessing different extents of unsaturation. Biochem. J vol. 247 (1987).
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