José Manuel Horcas Nieto

167 6 iPSC-derived liver organoids as a tool to study Medium Chain Acyl-CoA Dehydrogenase deficienc Chapter iPSC-derived liver organoids as a tool to study Medium Chain Acyl-CoA Dehydrogenase deficiency José. M Horcas-Nieto1*, Ligia A Kiyuna1*, Miriam Langelaar-Makkinje1, Albert Gerding1,2, Mathilde J. C. Broekhuis3 Flavio Bonanini4, Madhulika Singh5, Dorota Kurek4, Amy C. Harms5,, Thomas Hankemeier5,, Floris Foijer3, Barbara M. Bakker1$ 1 Laboratory of Paediatrics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; 2 Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; 3. European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; 4. Mimetas, Leiden, The Netherlands; 5. Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands * These authors contributed equally to this work § Corresponding author: Prof. dr. Barbara M Bakker Department of Pediatrics, University of Groningen, University Medical Center Groningen Antonius Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands, Building 3226. Postbus 196, 9700 AD Groningen, The Netherlands (Internal ZIP Code EA12) Phone: +31 50 361 1542 Email: b.m.bakker01@umcg.nl Submitted

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