José Manuel Horcas Nieto

214 Chapter 7 19. Chitrangi, S., Vaity, P., Jamdar, A. & Bhatt, S. Patient-derived organoids for precision oncology: a platform to facilitate clinical decision making. BMC Cancer 23, (2023). 20. Turhan, A. G. et al. iPSC-Derived Organoids as Therapeutic Models in Regenerative Medicine and Oncology. Front Med (Lausanne) 8, (2021). 21. Touw, C. M. et al. In vitro and in vivo consequences of variant medium-chain acyl-CoA dehydrogenase genotypes. Orphanet J Rare Dis 8, (2013). 22. Touw, C. M. L. et al. Risk stratification by residual enzyme activity after newborn screening for medium-chain acyl-CoA dehyrogenase deficiency: Data from a cohort study. Orphanet J Rare Dis 7, (2012). 23. Bordbar, A. et al. Personalized Whole-Cell Kinetic Models of Metabolism for Discovery in Genomics and Pharmacodynamics. Cell Syst 1, 283–292 (2015). 24. Saa, P. A. & Nielsen, L. K. Formulation, construction and analysis of kinetic models of metabolism: A review of modelling frameworks. Biotechnol Adv 35, 981–1003 (2017). 25. Odendaal, C. et al. Personalised modelling of clinical heterogeneity between mediumchain acyl-CoA dehydrogenase patients. BMC Biol 21, 184 (2023). 26. Moreno-Sánchez, R., Saavedra, E., Rodríguez-Enríquez, S. & Olín-Sandoval, V. Metabolic Control Analysis: A tool for designing strategies to manipulate metabolic pathways. J Biomed Biotechnol 2008, (2008). 27. Osumi, T., Hashimoto, T. & Ui, N. Purification and Properties of Acyl-CoA Oxidase from Rat Liver 1. J Biochem 87, 1735–1746 (1980). 28. Inestrosa, N. C., Bronfman, M. & Leighton, F. Detection of Peroxisomal Fatty AcylCoenzyme A Oxidase Activity. Biochem. J 182, 779–788 (1979). 29. Kim, J., Koo, B. K. & Knoblich, J. A. Human organoids: model systems for human biology and medicine. Nature Reviews Molecular Cell Biology vol. 21 571–584 Preprint at https:// doi.org/10.1038/s41580-020-0259-3 (2020). 30. Jensen, K. B. & Little, M. H. Organoids are not organs: Sources of variation and misinformation in organoid biology. Stem Cell Reports 18, 1255–1270 (2023). 31. Li, Y., Tang, P., Cai, S., Peng, J. & Hua, G. Organoid based personalized medicine: from bench to bedside. Cell Regeneration 9, (2020). 32. Bose, S., Clevers, H. & Shen, X. Promises and challenges of organoid-guided precision medicine. Med 2, 1011–1026 (2021). 33. Brandenberg, N. et al. High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays. Nat Biomed Eng 4, 863–874 (2020). 34. van Mever, M. et al. Profiling acidic metabolites by capillary electrophoresis-mass spectrometry in low numbers of mammalian cells using a novel chemical derivatization approach. Analytical Science Advances 3, 3–13 (2022). 35. He, B. et al. Analytical techniques for biomass-restricted metabolomics: An overview of the state-of-the-art. Microchemical Journal vol. 171 Preprint at https://doi.org/10.1016/j. microc.2021.106794 (2021). 36. Kasai, R. D. et al. A review on hydrogels classification and recent developments in biomedical applications. International Journal of Polymeric Materials and Polymeric Biomaterials (2022) doi:10.1080/00914037.2022.2075872.

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