33 2 Organoids as a model to study intestinal and liver dysfunction in severe malnutrition Chapter Organoids as a model to study intestinal and liver dysfunction in severe malnutrition José M. Horcas-Nieto1*, Christian J. Versloot1*, Miriam Langelaar-Makkinje1, Albert Gerding1,2, Tjasso Blokzijl3, Mirjam H. Koster1, Mirjam Baanstra4, Ingrid A. Martini2, Robert P. Coppes4, Céline Bourdon5, Sven C.D. van Ijzendoorn4, Peter Kim5,8, Robert H.J. Bandsma1,5-7§, Barbara M. Bakker1§ 1. Laboratory of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, The Netherlands; 2. Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; 3. Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; 4. Department of Biomedical Sciences of Cell & Systems, section Molecular Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; 5. Translational Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada; 6. Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; 7. Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, Toronto, ON, Canada; 8. Department of Biochemistry, University of Toronto, Toronto, ON, Canada. * These authors contributed equally to this work § Corresponding authors: Prof. dr. Barbara M Bakker Department of Pediatrics, University of Groningen, University Medical Center Groningen Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands Phone: +31 50 361 1542 Email: b.m.bakker01@umcg.nl Robert Bandsma, MD, PhD Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children,555 University Avenue, M5G 1X8, Toronto, Ontario, Canada Phone: +1 416-813-7654 Email: robert.bandsma@sickkids.ca Published in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2022) https://doi.org/10.1016/j.bbadis.2022.166635
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