89 4 Docosahexaenoic acid prevents peroxisomal and mitochondrial protein loss in a murine hepatic organoid model Chapter Docosahexaenoic acid prevents peroxisomal and mitochondrial protein loss in a murine hepatic organoid model of severe malnutrition José M. Horcas-Nieto1, W. Alfredo Rios-Ocampo1, Miriam Langelaar-Makkinje1, Rinse de Boer2, Albert Gerding1,3, Serhii Chornyi4, Ingrid A. Martini3, Justina C. Wolters1,5, Ronald J. A. Wanders4, Hans R. Waterham4 , Ida J. Van der Klei2, Robert H.J. Bandsma1,6,7,8, Johan W. Jonker1, Barbara M. Bakker1§ 1. Laboratory of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, The Netherlands; 2. Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands; 3. Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; 4. Laboratory Genetic Metabolic Diseases, Amsterdam UMC Location AMC, University of Amsterdam, Amsterdam, Netherlands; 5. Interfaculty Mass Spectrometry Center, University of Groningen, University Medical Center Groningen, The Netherlands; 6. Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada; 7. Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; 8. Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, Toronto, ON, Canada § Corresponding author: Prof. dr. Barbara M Bakker Department of Pediatrics, University of Groningen, University Medical Center Groningen Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands Phone: +31 50 361 1542 Email: b.m.bakker01@umcg.nl Manuscript in preparation
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