José Manuel Horcas Nieto

Chapter 1: General Introduction	7
Chapter 2: Organoids as a model to study intestinal and liver dysfunction in severe malnutrition	33
Chapter 3: Towards Automatization of Organoid Analysis: A Deep Learning Approach to Localize and Quantify Organoids Images	73
Chapter 4: Docosahexaenoic acid prevents peroxisomal and mitochondrial protein loss in a murine hepatic organoid model of severe malnutrition	89
Chapter 5: Establishing a peroxisomal β-oxidation computational kinetic model to understand the effects of amino-acid restriction on peroxisomal β-oxidation	129
Chapter 6: iPSC-derived liver organoids as a tool to study Medium Chain Acyl-CoA Dehydrogenase deficiency	167
Chapter 7: General Discussion	201
Appendices	217
Summary	218
Samenvatting	222
Resumen para público no científico	227
Acknowledgments	232
Curriculum vitae	238
List of publications	240

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