153 5 General Discussion 19 O’Neill LAJ, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nat Rev Immunol. 2016 Sep;16(9):553–65. 20 Lottes RG, Newton DA, Spyropoulos DD, Baatz JE. Alveolar type II cells maintain bioenergetic homeostasis in hypoxia through metabolic and molecular adaptation. Am J Physiol Lung Cell Mol Physiol. 2014 May;306(10):L947. 21 Khaing P, Summer R. Maxed out on glycolysis: Alveolar macrophages rely on oxidative phosphorylation for cytokine production. Am J Respir Cell Mol Biol. 2020;62(2):139–40. 22 Leus NGJ, Van Der Wouden PE, Van Den Bosch T, Hooghiemstra WTR, Ourailidou ME, Kistemaker LEM, et al. HDAC 3-selective inhibitor RGFP966 demonstrates antiinflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity. Biochem Pharmacol. 2016 May;108:58–74. 23 Leus NGJ, Van Den Bosch T, Van Der Wouden PE, Krist K, Ourailidou ME, Eleftheriadis N, et al. HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice. Sci Rep. 2017 Mar;7(1):1–18. 24 Andrews JT, Voth DE, Huang SCC, Huang L. Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection. Front Cell Infect Microbiol. 2022 Jul;12. DOI: 10.3389/FCIMB.2022.934460 25 Viola A, Munari F, Sánchez-Rodríguez R, Scolaro T, Castegna A. The metabolic signature of macrophage responses. Front Immunol. 2019 Jul;10(JULY):1462. 26 Vasse GF, Kühn PT, Zhou Q, Bhusari SA, Reker-Smit C, Melgert BN, et al. Collagen morphology influences macrophage shape and marker expression in vitro. J Immunol Regen Med. 2018 Mar;1:13–20. 27 Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science (1979). 2017 May;356(6337):513–9. 28 Boorsma CE, Draijer C, Melgert BN. Macrophage Heterogeneity in Respiratory Diseases. Mediators Inflamm. 2013 Feb;2013:1–19. 29 Parameswaran N, Patial S. Tumor Necrosis Factor-α Signaling in Macrophages. Crit Rev Eukaryot Gene Expr. 2010;20(2):87–103. 30 Arango Duque G, Descoteaux A. Macrophage Cytokines: Involvement in Immunity and Infectious Diseases. Front Immunol. 2014 Oct;5. DOI: 10.3389/fimmu.2014.00491 31 Baran P, Hansen S, Waetzig GH, Akbarzadeh M, Lamertz L, Huber HJ, et al. The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling. Journal of Biological Chemistry. 2018 May;293(18):6762–75.
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