159 6 English summary expression but no significant alterations in enzyme activity in this metabolic pathway, again highlighting the intricate interplay between macrophages and their microenvironment, critical in tissue repair to fibrosis in the lungs. Overall, this thesis summarized the core findings of the field, emphasizing the diverse metabolic adaptations of macrophages in conditions like obesity, type 2 diabetes mellitus, and lung disorders. It showcased the capacity of macrophages to adapt their metabolism based on distinct tissue environments, significantly influencing their behavior. Furthermore, this thesis showcased the potential of KDACis in reducing inflammation, offering promising avenues for treating chronic inflammatory diseases like COPD. This thesis stressed the importance of employing various techniques to characterize macrophage behavior under diverse conditions comprehensively. For future directions, this thesis suggests using single-cell metabolomics, proteomics and transcriptomics to unravel macrophage population heterogeneity and identify novel metabolic pathways crucial in disease states. It also advocates for an integrated multi-omics approach, combining various omics techniques for comprehensive macrophage profiling, potentially revealing crucial regulators and therapeutic targets. In conclusion, this thesis established a foundational understanding of macrophage behavior within chronic diseases. It hinted at tailored treatments targeting macrophage metabolism to alleviate chronic inflammation, potentially improving patient prognosis significantly.
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