TABLE OF CONTENTS Chapter 1 General Introduction 7 Chapter 2 Meta-inflammation and metabolic reprogramming of macrophages in diabetes and obesity: the importance of metabolites 23 Chapter 3 Effects of lysine deacetylase inhibitor treatment on LPS responses of alveolar-like macrophages 59 Chapter 4 Collagen Type I Alters the Proteomic Signature of Macrophages in a Collagen Morphology-Dependent Manner 103 Chapter 5 General Discussion 139 Appendix English summary 158 Nederlandse Samenvatting 160 Italian summary (Riassunto in Italiano) 162 Acknowledgements 164 Curriculum Vitae 169
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