88 Chapter 3 SUPPLEMENTARY MATERIAL Supplementary Figure 1: Effects of KDAC inhibitors MS275 or RGFP966 on TNF-α, IL-10, and IL-6 excretion in culture supernatant of alveolar-like macrophages stimulated with lipopolysaccharide (LPS) for 4 hours. (A) Effect of KDAC inhibition and LPS stimulation on IL-10 cytokine excretion levels. (B) Effect of KDACi inhibition and LPS stimulation on TNF-α cytokine excretion levels. (C) Effect of KDACi inhibition and LPS stimulation on IL-6 cytokine excretion levels. A Wilcoxon test was used to compare control versus LPS stimulation. Groups stimulated with or without KDAC inhibitors were compared using a Friedman test with a Dunn’s correction for multiple testing (n=5). P<0.05 was considered significant. In panel (C) no statistical analysis was performed as only 2 biological replicates were compared.
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