92 Chapter 3 Supplementary Table 1: Protein expression in alveolar-like macrophages after KDAC inhibitor treatment in combination with LPS or not. Cells were incubated with and without KDAC inhibitor MS275 (MS275+LPS, LPS) for 16 h. After 16 h cells were stimulated with LPS (10 ng/mL). Protein expression levels were measured with an untargeted approach. Protein Corrected p value Fold change MS275+LPS vs LPS Median LPS (Log2 Intensity) Median MS275+LPS (Log2 Intensity) Protein INCA1 0.038 15.78 15.74 19.22 Junctional adhesion molecule A 0.022 4.91 13.53 15.84 Macrophage metalloelastase 0.038 4.69 13.8 16.59 Glutamine synthetase 0.007 3.88 16.03 17.18 Hyccin 0.03 3.73 12.52 14.83 Plasminogen activator inhibitor 1 0.028 3.56 14.08 16.73 39S ribosomal protein L37, mitochondrial 0.031 3.43 13.69 15.54 Cytoskeleton-associated protein 4 0.001 3.31 14.39 16.36 Platelet glycoprotein 4 0.006 3 14.69 16.57 Conserved oligomeric Golgi complex subunit 4 0.029 2.99 12.82 14.46 2-(3-amino-3-carboxypropyl) histidine synthase subunit 2 0.018 2.97 12.13 13.42 Cyclin-dependent kinase inhibitor 1 0.014 2.88 14.54 16.12 G protein-coupled receptor kinase 6 0.023 2.81 13.42 15.29 Fibronectin type III domaincontaining protein 3B 0.029 2.58 12.65 14.2 5-aminolevulinate synthase, nonspecific, mitochondrial 0.026 2.58 13.16 15.73 Transmembrane protein 245 0.03 2.56 14.16 15.21 Microtubule-associated protein RP/EB family member 3 0.014 2.49 14.86 16.15 CDGSH iron-sulfur domaincontaining protein 3, mitochondrial 0.048 2.41 14.19 15.49 ER membrane protein complex subunit 1 0.033 2.39 16.05 17.04 Uncharacterized protein KIAA0513 0.037 2.19 13 14.64 Vacuolar protein sortingassociated protein 16 homolog 0.036 2.18 15.27 15.92 Bcl-2-like protein 11 0.04 2.17 14.13 14.82 Aldehyde dehydrogenase, dimeric NADP-preferring 0.024 2.17 16.48 17.78 Microtubule-associated protein RP/EB family member 2 0.01 2.1 14.64 15.93 Stimulator of interferon genes protein 0.047 2.07 14.75 15.5 Store-operated calcium entryassociated regulatory factor 0.046 2.01 16.02 17.13 ADP-ribosylation factor-like protein 8B 0.038 1.95 17.41 18.82
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