98 Chapter 3 Supplementary Table 2: Protein expression in alveolar-like macrophages after KDAC inhibitor treatment in combination with LPS or not. Cells were incubated with and without KDAC inhibitor RGFP966 (RGFP966+LPS, LPS) for 16 h. After 16 h cells were stimulated with LPS (10 ng/mL). Protein expression levels were measured with an untargeted approach. Protein Corrected p value Fold change RGFP+LPS vs LPS Median LPS (Log2 Intensity) Median RGFP+LPS (Log2 Intensity) Pre-mRNA-splicing factor 38A 0.041 2.49 13.97 16.6 Protein spire homolog 1 0.011 2.19 11.44 12.13 Class E basic helix-loop-helix protein 41 0.017 2.01 12.17 13.08 CUGBP Elav-like family member 1 0.028 1.94 12.41 13.31 Prolactin-7C1 0.01 1.7 12.33 13.54 Ubiquitin carboxyl-terminal hydrolase 10 0.015 1.59 14.8 15.39 NAD-dependent malic enzyme, mitochondrial 0.036 1.57 15.63 16.51 Transcription initiation factor TFIID subunit 10 0.029 0.48 16.21 14.92 Protein disulfide isomerase Creld2 0.021 0.53 16.92 16.13 Volume-regulated anion channel subunit LRRC8C 0.018 0.55 15.66 15.22 Protein Dr1 0.036 0.55 15.86 15.29 LIM and senescent cell antigen-like-containing domain protein 1 0.017 0.6 16.22 15.5 U6 snRNA-associated Sm-like protein LSm6 0.05 0.61 16.03 15.41 WASH complex subunit 3 0.034 0.62 15.84 15.28 Mediator of RNA polymerase II transcription subunit 10 0.047 0.63 15 14.26 Acylphosphatase-1 0.02 0.64 16.93 16.32 Charged multivesicular body protein 3 0.031 0.66 16.68 15.98 Protein LTV1 homolog 0.012 0.67 16.97 16.35 Guanylate-binding protein 1 0.017 0.68 13.13 12.57 Calmodulin-1;Calmodulin2;Calmodulin-3 0.006 0.68 17.65 17.01
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