85 3.2 Clinical evaluation and resonance frequency analysis in Down Syndrome Overall mean ISQ increased from 46.2 at loading to 56.7 at 12 months, ISQ H increased from 47.9 to 56.9 and ISQ L from 44 to 55.4. Although statistical significance varies at each review point, when compared to the baseline statistically significance is seen from the 3- month review point [Table 2, Fig. 1]. 3.6 ISQ and fixture failure relationship Statistical analysis of the relationship between atraumatic fixture failures and ISQ was not performed due to small sample size (n = 2). In addition, mean BMI centile of the fixture failure patients (19.9th centile SD, 1.9) did not differ from the mean for the entire cohort (19.1st centile, SD 3.3). Figure 1: Line plot of change in ISQ recording with standard deviation at each review point. This demonstrates the change in ISQ recorded over time.
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