Chapter 4 128 Supplementary materials 4 Analyses per menstrual phase, OC generation and including IUD users Sleep quality and sleep disruptions For the supplementary materials, participants were excluded if OC generation was missing (n=4), or if they were naturally cycling and their CAR measurement was taken more than 28 days since the last recorded day of bleeding (n=19). In Supplementary Table S4.1, reported sleep quality and sleep disruptions are reported in subgroups per hormonal contraceptive form (i.e., IUD use, OC generation) and menstrual phase (i.e., within 14 days after start of the last menstruation was categorized as follicular phase, more than 14 days since the start of the last menstruation was categorized as luteal phase). An unadjusted sensitivity analysis comparing only NC women who were in the follicular phase (n=53) with all OC users (n=31) indicated that the sleep quality scores did not significantly differ between OC users and NC women in the follicular phase (0.75, 95% CI: -0.195 to 1.686, p=0.11), and that OC users were not more likely to report disrupted sleep compared to NC women (0.529, 95% CI: 0.406 to 0.648, p=0.65). CAR per sex, hormonal contraceptive form and menstrual cycle. Sensitivity analyses comparing all OC users, regardless of OC generation, to NC women in the follicular phase indicated that OC users had a significantly lower CAR AUCis than NC women in the follicular phase (-206.95, 95% CI: -336.58 to -77.32, p<0.01). As shown in Supplementary Table S4.2, the CAR did not differ between NC women in the follicular phase compared to NC women in the luteal phase, nor did it differ compared to IUD users or users of 2nd generation OCs. Users of 3rd generation OCs showed a lower CAR than NC women in the follicular phase (-261.45, 95% CI: -418.23 to -104.67, p<0.01) and men showed a lower CAR than NC women in the follicular phase (-114.75, 95% CI: -199.01 to -30.48, p<0.01).
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