Margot Morssinkhof

Chapter 4 130 Table S4.2. Cortisol Awakening Response characteristics per group, stratified by sex, form of hormonal contraceptive use and menstrual cycle. Users of 1st and 4th generation oral contraceptives were excluded due to very low sample sizes (n=2 and n=1, respectively). Naturally cycling women – follicular phase Naturally cycling women - luteal phase Oral contraceptive users – 2nd generation Oral contraceptive users – 3rd generation Intrauterine device users Men Absolute awakening value Mean, standard deviation 12.58 (5.43) n=52 8.87 (3.92) n=14 10.09 (4.53) n=9 12.29 (8.41) n=15 11.43 (6.64) n=12 9.77 (5.14) n=122 Absolute value evening Mean, standard deviation 5.21 (2.23) n=50 2.21 (1.96) n=14 3.41 (2.25) n=8 6.13 (11.87) n=14 3.34 (2.74) n=11 2.77 (2.01) n=112 CAR AUCi (nmol/L*minutes) Mean, standard deviation 221.52 (312.14) n=52 281.33 (304.55) n=14 98.95 (181.84) n=9 -39.92 (206.51) n=13 123.24 (339.4) n=12 106.78 (220.94) n=117 Estimated group difference in AUCi (nmol/L*minutes) Marginal model B (95% CI), p Reference 59.81 (-92.42 to 212.04) p=0.44 -122.57 (-305.11 to 59.96) p=0.19 -261.45 (-418.23 to -104.67) p<0.01 -98.29 (-260.21 to 63.63) p=0.23 -114.75 (-199.01 to -30.48) p<0.01

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