Chapter 5 148 3.5. Post-hoc analyses: moderating factors for insomnia symptoms Moderation analyses testing the role of hot flashes in trans men show that reported hot flashes do not significantly affect ISI scores at baseline or at follow-up measurements. In the trans women, moderation analyses show significant interactions between hot flashes and ISI scores. Trans women who reported hot flashes report significantly higher ISI scores at the 6- and 9-month follow-up visits compared to trans women who did not report hot flashes (3.07 (95% CI: 0.84; 5.29); 3.34 (95% CI: 0.96; 5.71), respectively). At the 12-month follow-up, when 27 trans women still experienced hot flashes and 52 participants did not, there was no significant interaction between hot flashes and ISI scores anymore. The mean scores and 95% confidence intervals of trans women with and without hot flashes are also displayed in Figure 5.4, and full results of the moderation analyses are reported in the supplementary materials. Figure 5.4. Mean Insomnia Severity Index (ISI) scores and corresponding 95% confidence intervals of trans women who either did or did not report hot flashes during Gender-Affirming Hormone Therapy (GAHT). Asterisks indicate significant differences (p<0.05) in ISI scores between participants who report hot flashes and participants who do not.
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