Sex hormones, insomnia, and sleep quality: subjective sleep in the first year of hormone use 161 For non-hypogonadal cisgender females in the reproductive age, reference values of testosterone are between 0.3 nmol/L and 1.6 nmol/L and reference values of estradiol are between 31 pmol/L and 2864 pmol/L, depending on the menstrual phase (Amsterdam UMC Endocrinologisch Lab et al., z.d.; Verdonk et al., 2019). For cisgender females after menopause, the reference values of estradiol are below 26 pmol/L (Amsterdam UMC Endocrinologisch Lab et al., z.d.; Verdonk et al., 2019). Serum hormone results Supplementary Table S5.1 displays the median and interquartile range of serum hormone levels (testosterone and estradiol) at each measurement of the study. As shown below, trans men’s testosterone serum levels go from the cisgender female reference range to the cisgender male reference range after 3 months of GAHT. Trans women’s testosterone serum levels go from the cisgender male reference range to the cisgender female reference range, and their estradiol serum levels go from the cisgender male reference range to the cisgender female reference range, and they sit well above the levels of postmenopausal cisgender females. Table S5.1. Serum hormone levels at each measurement timepoint, displayed per median and interquartile range. Trans men Testosterone (nmol/L) Estradiol (pmol/L) Baseline 0.9 (0.6 to 1.3) 154.2 (91.8 to 370.8) 3 months after GAHT 15.3 (11.2 to 21.2) 148.3 (102.9 to 220.2) 6 months after GAHT 18.6 (13.4 to 24.9) 146.7 (104.4 to 194.6) 9 months after GAHT 18.1 (15.2 to 22.6) 152.2 (117.9 to 196.4) 12 months after GAHT 20.9 (15.3 to 25.3) 146.2 (106.6 to 207.7) Trans women Testosterone (nmol/L) Estradiol (pmol/L) Baseline 17.0 (13.0 to 21.6) 91.8 (90.0 to 126.4) 3 months after GAHT 0.4 (0.4 to 0.7) 269.5 (168.9 to 389.2) 6 months after GAHT 0.4 (0.4 to 0.7) 257.0 (127.0 to 350.6) 9 months after GAHT 0.4 (0.4 to 0.6) 260.7 (181.2 to 381.8) 12 months after GAHT 0.4 (0.3 to 0.8) 279.0 (209.6 to 346.0)
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