Influence of sex hormone use on sleep architecture in a transgender cohort 175 At baseline, 50% of transmasculine participants used a form of cycle regulation: 11.1% used progestin-only oral forms, 22.2% used progestin-only non-oral forms, and 16.7% used a combined oral contraceptive with estradiol and progestins. After starting GAHT use, 89% of the transmasculine participants used testosterone in the form of testosterone gel, and 11% used testosterone in the form of short-acting testosterone ester injections. In the transfeminine participants after GAHT start, 53% used estradiol in the form of oral estradiol tablets, 38% used transdermal estradiol patches and 9% used transdermal estradiol gel. All transfeminine participants used combined estradiol use with anti-androgen use, with 84% of transfeminine participants using short-acting triptorelin injections, 9.4% using short-acting leuproreline injections and 9.4% using oral cyproterone acetate. All GAHT forms at each follow-up are also reported in Table S6.1 (see Supplementary Materials). Figure 6.1. Inclusion flowchart of the RESTED study, showing inclusion rates and sample sizes per group and timepoint in the study.
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