Influence of sex hormone use on sleep architecture in a transgender cohort 191 Table S6.2. Sleep architecture during GAHT – with main predictor for devices in active mode. TM TF Means and SD or median and IQR Estimated difference active vs. inactive modea. Means and SD or median and IQR Estimated difference active vs. inactive modea. Setting Inactive Active Inactive Active Measurement weeks Baseline: n=33 3MO: n=15 Baseline: n=3 3MO: n=11 Beta, 95% confidence interval, p-value Baseline: n=31 3MO: n=23 Baseline: n=1 3MO: n=1 Beta, 95% confidence interval, p-value SOL (minutes) 17.8 (7.96 to 33.1) 20.02 (7.96 to 36.7) -15.5% (-39.1% to 17.7%) p=0.31 13.98 (7.29 to 27.25) 16.87 (12.22 to 26.85) 3.21% (-10.95 to 19.58) p=0.68 TST (hours) 7.3 (1.4) 7.6 (1.6) 0.144 (-0.30 to 0.59) p=0.53 6.49 (1.33) 6.64 (0.67) 0.6594 (-0.251 to 1.559) p=0.15 WASO (minutes) 20.27 (12.8 to 38.4) 21.0 (15.4 to 28.1) 4.2% (-18.7 to 33.4) p=0.75 15.79 ( 9.83 to 37.54) 21.66 (11.18 to 32.1) -9.998% ( -47.56 to 54.47) p=0.70 NRI 1 (0 to 2) 1 (0 to 2) 6.96% (-10.4% to 27.8%) p=0.46 1 (0 to 1.5) 1 (0 to 2) -17.26% (-44.38 to 23.26) p=0.35 NRA 27 (21 to 40) 26.5 (19 to 43) -3.1% ( -17.6 to 13.9) p=0.70 27 (41 to 18) 40 (15.5 to 53.5) - 13.80% (-41.08 to 26.17) p=0.45 SWS (minutes) 87 (31) 93 (32) -1.5 (-5.5 to 8.59) p=0.67 86 (30) 82 (23) -6.31 (-21.53 to 8.96) p=0.42 % SWS 20.0% (7.3%) 21.0% (8.0%) -0.04% (-1.88 to 1.80) p=0.95 22.6 (8.05) 20.82 (7.02) -4.3247% (-9.2956 to 0.692) p=0.091 REM sleep duration (minutes) 118.9 (45.5) 119.1 (38.9) -9.90 (-23.27 to 3.49) p=0.149 114.26 (42.9) 106.91 (19.67) 7.938 (-20.63 to 36.28) p=0.58 REM sleep latency (minutes) 82 (33.5 to 125.5) 68 (28.8 to 101.5) -1.9% (-29.6 to 39.3) p=0.95 81.00 (22.5 to 111.5) 89.0 (39.5 to 95.0) 29.74% (- -42.66 to 90.51) p=0.53 a. Analyzed using a linear mixed model with measurement phase and device setting as fixed predictors and a random intercept per participant, with inactive mode as the reference category.
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