Chapter 7 206 22-minute later MSFsc in the adjusted model and a 30-minute later MSFsc in the sensitivity analysis. The TM group shows no changes in the sleep duration after 3 months of GAHT in the unadjusted or adjusted model. In the sensitivity analysis, the TM group shows a trend towards a longer sleep duration: the sleep duration is estimated to be 27 minutes longer (p=0.054) in TM users who did not use an alarm clock on free days. All results from the TM group are displayed in Table 7.2 and Figure 7.2. 3.3. Transfeminine group In the TF group, the adjusted model for MSFsc showed 21-minute earlier MSFsc after 3 months of GAHT compared to baseline. The sensitivity analysis showed a significant 17-minute earlier MSFsc in TF participants who did not use an alarm clock on free days. The TF group showed no significant changes in sleep duration after 3 months of GAHT. All results from the TF group are also displayed in Table 7.2 and Figure 7.2. Table 7.2. Sleep duration and (sleep-corrected) Midpoint of Sleep on Free days (MSFsc) obtained from the µMCTQ in the transmasculine (TM) group and the transfeminine (TF) group. All variables are reported in clock hours (hh:mm). Outcome in hh:mm Transmasculine group Predictor (n) Mean (SD) Unadjusted model Estimated change from baseline (95% CI: L; H) p-value) Adjusted model Estimated change from baseline (95% CI: L; H) p-value) Sensitivity model1. Estimated change from baseline (95% CI: L; H) p-value) MSFsc Baseline (48) 04:35 (01:26) Reference Reference Reference 3-month follow up (38) 04:54 (01:37) 00:20 (-00:02; 00:41) p=0.084 00:24 (00:03; 00:45) p=0.03 00:30 (00:03; 00:58) p=0.039 Sleep duration Baseline (48) 08:28 (01:14) Reference Reference Reference 3-month follow up (38) 08:42 (01:04) 00:13 (-00:08, 00:35) p=0.22 00:14 (-00:08, 00:36) p=0.22 00:27 (00:01; 00:55) p=0.054 Outcome in hh:mm Transfeminine group Time point, months after start GAHT (n) Mean (SD) or median (IQR) 1. Unadjusted model Estimated change from baseline (95% CI: L; H) p-value) Adjusted model Estimated change from baseline (95% CI: L; H) p-value) Sensitivity model1. Estimated change from baseline (95% CI: L; H) p-value) MSFsc Baseline (44) 04:56 (01:27) Reference Reference 3-month follow up (37) 04:39 (01:02) -00:15 (-00:35; 00:05) p = 0.14 -00:21 (-00:38; -00:04) p=0.023 -00:17 (-00:32; -00:03) p=0.03 Sleep duration Baseline (44) 08:26 (01:05) Reference Reference 3-month follow up (37) 08:25 (00:54) 00:00 (-00:21; 00:21) p=0.99 -00:02 (-00:22; 00:17) p=0.83 -00:02 (-00:22; 00:17) p=0.86 1. Excluding participants who use alarm clocks on free days. Sample sizes are n=31 at baseline and n=24 at 3-month-follow up for the TM group and n=29 at baseline and n=25 at 3 month-follow up for the TF group.
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