Chapter 2 66 Supplementary Material 2.A Analysis of individual items from the WHI-IRS and item 4 from the IDS-SR using a multivariable linear mixed effects model adjusting for age, highest education and birth country. The analysis shows that the WHI-IRS items 2 and 3 show the strongest difference between OC and NC measurements, as displayed in Figure 2.3 and Table 2.3. Figure 2.3. Forest plot visualizing the unadjusted mean scores, the adjusted estimated difference in WHI-IRS items and the IDS-SR sleep items between OC and NC measurements. Estimated scores are calculated using a model adjusting for age, education and birth country. WHI-IRS = Women’s Health Initiative-Insomnia Rating Scale, IDS-SR = Self-Reported Inventory of Depressive Symptoms, NC = naturally cycling, OC = oral contraceptives, and SE = Standard Error. Table 2.3. Item differences in insomnia scores from the WHI-IRS and IDS–SR. Items Raw scores (mean, SD) Adjusted model results NC measurements OC measurements B (95% CI) p-value WHI-IRS 1: Falling asleep at night 2.05 (1.25) 2.07 (1.24) -0.04 (-0.15, -0.06) 0.39 WHI-IRS 2: Waking up at nighttime 2.76 (1.46) 2.88 (1.43) 0.28 (0.16, 0.39) <0.0001 WHI-IRS 3: Morning wakening earlier than planned 2.22 (1.40) 2.29 (1.40) 0.19 (0.08, 0.31) 0.001 WHI-IRS 4: Falling asleep morning 1.94 (1.22) 1.90 (1.25) 0.07 (-0.03, 0.17) 0.019 WHI-IRS 5: Rested after sleep 2.84 (0.91) 2.85 (0.91) 0.08 (0.00, 0.16) 0.043 WHI-IRS 6: Sleep duration 3.60 (1.49) 3.43 (1.21) 0.06 (-0.03, 0.16) 0.19 IDS-SR 1: Falling asleep night 1.68 (0.97) 1.70 (0.96) -0.02 (-0.10, 0.06) 0.65 IDS-SR 2: Waking up nighttime 2.09 (0.99) 2.16 (0.98) 0.23 (0.14, 0.31) <0.0001 IDS-SR 3: Waking morning 1.31 (0.70) 1.33 (0.71) 0.05 (-0.01, 0.11) 0.13 IDS-SR 4: Hypersomnia 1.46 (0.67) 1.59 (0.74) 0.06 (0.00, 0.13) 0.038 WHI-IRS=Women’s Health Initiative-Insomnia Rating Scale, IDS-SR=Self-Reported Inventory of Depressive Symptoms, NC=naturally cycling and OC=oral contraceptives. Model adjusted for age, highest education and birth country.
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