Changes in depression symptom profile with gender-affirming hormone use in transgender persons 85 Table 3.2. Results show the estimated changes in IDS-SR scores and subscale scores after 3 and 12 months of GAHT in all participants who contributed a baseline and at least one follow-up measurement. Each cell displays the median score and corresponding 25th and 75th percentile, and follow-up time points display the estimated percentages of change relative to baseline, the corresponding 95% confidence interval and p-value. Overall cohort Transmasculine participants Transfeminine participants Time point Baseline 3 months 12 months Baseline 3 months 12 months Baseline 3 months 12 months n 135 125 85 80 70 54 56 55 31 Total 13 (8 to 24.3) 15 (10 to 20) -0.8%, (-10.1%; 9.4%), p=0.87 14 (9 to 22) -1.3%, (-11.7%; 10.3%), p=0.83 15 (9 to 26.5) 15 (9.3 to 19.8) -9.9%, (-20.7%; 2.3%), p=0.11 14 (8.3 to 24.8) -10.3%, (-21.9%; 3.1%), p=0.13 11.5 (6.8 to 21) 13 (10 to 19.5) 12.6%, (-2.8%; 30.5%), p=0.12 13 (9 to 21.5) 15.8%, (-3.1%; 38.4%), p=0.11 Mood 2 (0 to 3) 2 (0 to 3) -2.3%, (-12.1%; 8.6%), p=0.66 2 (0 to 4) 3.2%, (-8.5%; 16.3%), p=0.61 2 (0 to 3) 2 (0 to 3) -4.9%, (-17.1%; 9.2%), p=0.48 1 (0 to 3.8) -7.1%, (-20.1%; 7.9%), p= 0.34 2 (1 to 3) 2 (1 to 3) 1.1%, (-13.8%; 18.6%), p=0.89 2 (1.5 to 4.5) 24.3%, (2.6%; 50.6%), p=0.03 Anxiety 2 (0 to 5) 2 (0 to 4) -5.7%, (-14.5%; 4.1%), p=0.25 2 (0 to 3) -4.2%, (-14.3%; 7.1%), p=0.46 2 (0 to 5) 2 (0 to 3.8) -4.2%, (-16.0%; 9.1%), p=0.45 2 (0 to 3.8) -2.8%, (-15.6%; 12.0%), p= 0.63 2 (1 to 4) 2 (0 to 4) -7.7%, (-20.7%; 7.3%), p=0.30 1 (0.5 to 3) -5.9%, (-21.5%; 12.7%), p=0.51 Lethargy 2 (0 to 5) 2 (0 to 4) -7.7%, (-18.2%; 4.0%), p=0.19 2 (1 to 4) 1.3%, (-11.6%; 15.9%), p=0.86 2.5 (0.8 to 5) 2 (0 to 4) -16.3%, (-28.5%; -2.0%), p=0.03 2 (1 to 4.8) -2.3%, (-17.7%; 15.9%), p= 0.79 1.5 (0 to 4) 2 (0 to 4) 4.7%, (-12.8%; 25.7%), p=0.62 1 (0 to 4) 7.1%, (-14.1%; 33.3%), p=0.54 Somatic 0 (0 to 1) 0 (0 to 1) 1.3%, (-7.5%; 11.1%), p=0.77 0 (0 to 1) 3.0%, (-7.1%; 14.1%), p=0.58 1 (0 to 1) 0 (0 to 1) -4.4%, (-15.3%; 7.7%), p=0.46 1 (0 to 1) 3.8%, (-8.8%; 18.2%), p=0.58 0 (0 to 1) 0 (0 to 2) 9.6%, (-4.6%; 25.9%), p=0.20 0 (0 to 1) 1.0%, (-14.4%; 19.2%), p=0.91
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