Changes in depression symptom profile with gender-affirming hormone use in transgender persons 95 Supplementary materials 3.1. Sensitivity models: Age, study cohort, cycle regulation and incomplete GAHT Methods: Incomplete GAHT use in the TF group To assess whether TF participants with incomplete GAHT (meaning use of estradiol or anti-androgens, but not both) skewed the scores of the overall TF group, we conducted a sensitivity analysis assessing the interaction between GAHT completeness (i.e.. either complete GAHT or incomplete GAHT) and the IDS-SR outcomes. This was done through the addition of GAHT completeness as an interaction term with the time points (i.e. start of GAHT, 3 months after GAHT start or 12 months after GAHT start) in the linear mixed models. Results: Incomplete GAHT use in the TF group The results of this sensitivity analysis show that in the TF group with only complete GAHT, the IDS-SR mood subscale is still increased compared to baseline at 12 months after GAHT start. The full results are displayed below in Supplementary Table S3.1. The sample sizes in the group of incomplete GAHT users were deemed too small to draw any meaningful conclusions from the analyses in this group. Methods: Adjusted models for age, study cohort and cycle regulation To examine the possible role of age, study cohort and use of cycle regulation, testosterone form and estrogen form, these variables were added as covariates to the statistical models, and results from these analyses are displayed in Supplementary Table S3.2. Results: Adjusted models for age, study cohort and cycle regulation As shown in Supplementary Table S3.2, there was a significant positive association between age and depressive symptoms, but the addition of age did not strongly change the estimated changes after starting GAHT use. Study cohort, use of cycle regulation, testosterone form and estrogen form were not significantly associated with differences in IDS-SR scores.
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