Monitoring of Myocardial Involvement in ARVC | 123 Supplemental Table 1. Progression of deformation parameters (continued) At inclusion (n=82) (SD) Progression rate, 1 year (SE) At last follow-u (n=82) (SD) p-value for progression Post-systolic index mid Age 0-30 Age 30-50 Age 50+ 2.05 (5.3) 1.38 (5.2) 2.10 (4.8) 2.78 (6.1) 0.45 (0.12) 0.09 (0.10) 0.85 (0.23) 0.13 (0.23) 4.38 (12.7) 2.24 (4.2) 7.15 (18.6) 3.04 (8.1) <0.001 0.371 <0.001 0.580 Post-systolic index apex Age 0-30 Age 30-50 Age 50+ 0.50 (1.2) 0.39 (0.8) 0.68 (1.4) 0.36 (1.3) 0.34 (0.07) 0.02 (0.03) 0.63 (0.14) 0.22 (0.12) 2.23 (7.2) 0.57 (1.5) 4.30 (10.4) 1.31 (4.9) <0.001 0.617 <0.001 0.054 Values at inclusion and last follow-up are mean (SD). Yearly progression rate with standard errors (SE). P-values for progression are calculated by linear mixed model statistics with exchangeable covariance structure and random intercept. Abbreviations: LVEF, left ventricular ejection fraction; LV GLS, left ventricular global longitudinal strain; RVFWLS, right ventricular free wall longitudinal strain. Supplemental Table 2. Progression of local differences in the modelled tissue substrate At inclusion (n=82) Progression rate, 1 year(SE) At last followup (n=82) p-value for progression Contractility normalized SD, % Age 0-30 Age 30-50 Age 50+ 10.99 (5.94) 10.67 (7.02) 10.63 (5.25) 11.86 (5.61) 0.46 (0.11) 0.51 (0.14) 0.47 (0.18) 0.38 (0.31) 13.26 (9.95) 13.68 (11.12) 13.98 (10.97) 11.78 (6.75) <0.001 <0.001 0.008 0.220 Compliance normalized SD, % Age 0-30 Age 30-50 Age 50+ 44.84 (16.69) 43.10 (13.23) 46.94 (19.27) 43.96 (16.86) 1.07 (0.27) 1.53 (0.39) 0.55 (0.42) 1.69 (0.73) 55.53 (18.18) 56.33 (18.12) 52.96 (16.63) 58.19 (20.53) <0.001 <0.001 0.187 0.020 Mechanical activation delay SD, ms Age 0-30 Age 30-50 Age 50+ 16.40 (16.56) 14.99 (11.24) 18.11 (24.09) 15.67 (6.00) 0.80 (0.25) 0.81 (0.40) 0.71 (0.38) 1.10 (0.57) 19.92 (19.51) 21.20 (29.58) 20.16 (14.65) 18.09 (7.65) <0.001 0.044 0.057 0.052 Normalized heterogeneity between three RV free wall segments at inclusion and last follow-up are mean (SD). Yearly progression rate with standard errors. P-values for progression are calculated by linear mixed model statistics with exchangeable covariance structure and random intercept. 6
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