Early Detection of Genetic Cardiomyopathies in Relatives | 137 Central illustration. The clinical utility of deformation imaging in relatives at risk for genetic cardiomyopathies Deformation imaging on top of the standard clinical workup reveals early signs of disease in relatives of patients with genetic cardiomyopathy. These early mechanical abnormalities have prognostic value in DCM and ACM, and may be used in these relatives to tailor follow-up protocols. ACM, arrhythmogenic cardiomyopathy; DCM, dilated cardiomyopathy; ECG, electrocardiogram; HCM, hypertrophic cardiomyopathy; RV, right ventricle/ ventricular. Limitations All studies included in this review are retrospective observational studies, mostly with small sample sizes. The majority of the studies were performed in single centres, and the authors of this review were involved in 10 of the 29 included studies, particularly in the field of ACM. An inherent limitation of studies in relatives is that the rates of hard end-points are generally 7
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