140 | Chapter 7 Table 1. Included DCM studies First author, year, journal Design Study population Number Age (years) Genotype Verdonschot, 2020, JACC cvi CCS + LCS First-degree relatives with LVEF ≥55% 251 46 ± 17 Genetic testing in 44 relatives (18%), of which 32 (13%) genotype-positive (predominantly TTN) Taha, 2021, JACC cvi CCS + LCS Genotype-positive relatives (PLN p.Arg14del) without a history of VA, premature ventricular complex count <500/24h, LVEF ≥45% 139 33 [IQR 21-41] All PLN p.(Arg14del) Okten, 2017, Herz CCS First-degree relatives with LVEF ≥55% 77 35 [IQR 15] Not reported van der Bijl, 2019, EHJ cvi CCS Genotype-positive relatives with LVEF ≥55% 50 50 ± 15 Predominantly TTN (48%) and LMNA (20%) Paldino 2021, Int J Cardiology CCS + LCS Genotype-positive relatives with normal ECG and echocardiographic findings 41 37 ± 14 TTN, LMNA, FLNC, MYH7, TNNT2, MYBPC3, DSP, SCN5A, TMEM43, RBM20 Lakdawala, 2012, Circ Cardiovasc Img CCS Genotype-positive relatives with LVEF ≥55% and normal dimensions 12 25 ± 19 MYH7 (75%) and TPM1 (25%) Abbreviations: CCS = case-control study, DCM = dilated cardiomyopathy, ECG = electrocardiogram, GCS = global circumferential strain, GLS = global longitudinal strain, GRS = global radial strain, IQR = interquartile range, LCS = longitudinal cohort study, LV = left ventricle/ventricular, LVEF = left ventricular ejection fraction, LVMD = left ventricular mechanical dispersion, RVFWLS = right ventricular free wall longitudinal strain VA = ventricular arrhythmia.
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