Early Detection of Genetic Cardiomyopathies in Relatives | 141 Software Global deformation parameters Regional deformation parameters Control group Main result(s) TomTec GLS none 251 patients referred for chest pain, dyspnea or palpitations, with LVEF ≥55% GLS reduced in relatives (P<0.001). Reduced GLS associated with LVEF deterioration and adverse events (cardiac hospitalization and death) during follow-up GE Echopac GLS, LVMD, RVFWLS post-systolic shortening 70 healthy volunteers and patients from the outpatient clinic without cardiac disease Post-systolic shortening present in the LV apex in 31% of relatives with the PLN p.(Arg14del) variant; presence associated with nonsustained VA during follow-up. GE EchoPAC GLS, GLS rate, GCS, GCS rate, GRS, GRS rate, peak torsion none 86 healthy subjects with normal ECG and echo, and no family history of heart failure All global parameters significantly reduced in relatives GE EchoPAC GLS none 28 genotype-negative relatives GLS reduced in genotypepositive relatives (P=0.036) TomTec GLS, peak atrial longitudinal strain none 52 healthy volunteers and 17 genotype negative relatives GLS and peak atrial longitudinal strain reduced in genotypepositive relatives GE EchoPAC GLS, GLS rate, GCS, GCS rate, GRS, GRS rate none 29 genotype-negative relatives All parameters (except for GCS rate) reduced in genotypepositive relatives (P=0.018 for GLS) 7
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