144 | Chapter 7 Table 2. Included HCM studies (continued) First author, year, journal Design Study population Number Age (years) Genotype Software De, 2011, Am Heart J CCS Genotype-positive relatives (MYBPC3 c.3330+2T>G) with LV wall thickness <13 mm and no clinical signs or symptoms consistent with obstructive HCM 35 30 ± 14 All MYBPC3 c.3330+2T>G GE EchoPAC Grover, 2019, EHJ cvi CCS Genotype-positive relatives (MYBPC3) without LVH 18 38 ± 14 All MYBPC3 GE EchoPAC Peyrou, 2016, Int J Cardiovasc Img CCS Genotype-positive first-degree relatives with LV wall thickness <13 mm 14 43 ± 16 MYH7 (57%), MYBPC3 (29%) and TNNT2 (14%) GE EchoPAC Forsey, 2014, JASE CCS Genotype-positive first-degree relatives (children) without LVH 12 10 ± 5 MYBPC3 (43%), MYH7 (36%), MYHC (14%) and TPM1 (7%) GE EchoPAC Abbreviations: CCS = case-control study, ECG = electrocardiogram, GCS = global circumferential strain, GLS = global longitudinal strain, GRS = global radial strain, HCM = hypertrophic cardiomyopathy, IQR = interquartile range, LCS = longitudinal cohort study, LA = left atrium/atrial LV = left ventricle/ventricular, LVEF = left ventricular ejection fraction, LVH = left ventricular hypertrophy.
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