Early Detection of Genetic Cardiomyopathies in Relatives | 145 Global deformation parameters Regional deformation parameters Control group Main result(s) GLS Longitudinal strain in 18 LV segments 30 healthy volunteers with normal echo Basal septal longitudinal strain reduced in relatives (P=0.02), whereas basal posterior and mid posterior longitudinal strain increased (both P=0.001) GLS Longitudinal strain in 6 LV walls (averaged over wall) 11 genotype-negative siblings and 11 volunteers without cardiac disease or cardiovascular risk factors No significant differences reported GLS Longitudinal strain in 18 LV segments 32 healthy volunteers without LVH, without hypertension and without family history of HCM Basal inferoseptal and basal anteroseptal longitudinal strain reduced in relatives (p<0.05) Mean circumferential strain (basal/mid/apical), mean longitudinal strain (apical 4-chamber), basal/apical rotation and rotation rate, twist Circumferential strain in 18 segments, longitudinal strain in 6 segments (apical 4-chamber) 28 healthy volunteers from a normal control database Mean apical circumferential strain increased in relatives (P=0.04). Basal and apical rotation and LV twist increased in relatives, most marked at the apex (P=0.0001). 7
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