Early Detection of Genetic Cardiomyopathies in Relatives | 149 Global deformation parameters Regional deformation parameters Control group Main result(s) GLS (multilayer), RVFWLS Longitudinal strain in 17 LV segments (multilayer) and basal, mid and apical RV longitudinal strain 26 healthy volunteers, asymptomatic without history of premature cardiovascular disease Global parameters reduced in relatives. Regional parameters also reduced in LV free wall segments (epicardial more than endocardial), septal segments and RV mid and apical segments. none Basal RV time to onset shortening, (systolic) peak strain, postsystolic shortening and deformation pattern 84 healthy unrelated controls Abnormal deformation patterns more frequent in relatives than in controls (48% vs. 4%) none Longitudinal strain in basal/mid segments of LV lateral wall, septum and RV lateral wall Asymptomatic healthy male volunteers without family history of premature cardiovascular disease, no ECG abnormalities and no cardiac medication Reduced strain in basal septum of relatives Mean LV systolic peak strain (mean of 18 segments) Systolic peak strain and strain rate, and post-systolic shortening in 18 LV segments Healthy control subjects free of any cardiovascular disease (volunteers, unrelated to cases) Global strain equal, LV involvement in 25% relatives (vs 0% in controls) 7
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