Early Detection of Genetic Cardiomyopathies in Relatives | 157 SUPPLEMENTARY MATERIAL Supplementary methods Search queries MEDLINE (strain[tiab] OR deformation imaging[tiab] OR speckle tracking[tiab] OR GLS[tiab] OR mechanical dispersion[tiab]) AND ((genetic cardiomyopathy[tiab] OR inherited cardiomyopathy[tiab]) OR (“Cardiomyopathy, Hypertrophic”[Mesh] OR hypertrophic cardiomyopathy[tiab] OR HCM[tiab] OR hypertrophic obstructive cardiomyopathy[tiab] OR HOCM[tiab]) OR (“Cardiomyopathy, Dilated”[Mesh] OR dilated cardiomyopathy[tiab] OR DCM[tiab]) OR (“Arrhythmogenic Right Ventricular Dysplasia”[Mesh] OR arrhythmogenic cardiomyopathy[tiab] OR ACM[tiab] OR arrhythmogenic right ventricular cardiomyopathy[tiab] OR ARVC[tiab] OR arrhythmogenic right ventricular dysplasia[tiab] OR ARVD[tiab] OR ARVD/C[tiab]) OR (non-compaction[tiab] OR NCCM[tiab] OR LVNC[tiab] OR RVNC[tiab])) Embase (strain:ab,ti OR ‘deformation imaging’:ab,ti OR ‘speckle tracking’:ab,ti OR gls:ab,ti OR ‘mechanical dispersion’:ab,ti) AND (‘genetic cardiomyopathy’:ab,ti OR ‘inherited cardiomyopathy’:ab,ti OR ‘hypertrophic cardiomyopathy’:ab,ti OR hcm:ab,ti OR ‘hypertrophic obstructive cardiomyopathy’:ab,ti OR hocm:ab,ti OR ‘dilated cardiomyopathy’:ab,ti OR dcm:ab,ti OR ‘arrhythmogenic cardiomyopathy’:ab,ti OR acm:ab,ti OR ‘arrhythmogenic right ventricular cardiomyopathy’:ab,ti OR arvc:ab,ti OR ‘arrhythmogenic right ventricular dysplasia’:ab,ti OR arvd:ab,ti OR ‘arvd/c’:ab,ti OR ‘non compaction’:ab,ti OR nccm:ab,ti OR lvnc:ab,ti OR rvnc:ab,ti) Cochrane ((strain OR deformation imaging OR speckle tracking OR GLS OR mechanical dispersion) AND ((genetic cardiomyopathy OR inherited cardiomyopathy) OR (hypertrophic cardiomyopathy OR HCM OR hypertrophic obstructive cardiomyopathy OR HOCM) OR (dilated cardiomyopathy OR DCM) OR (arrhythmogenic cardiomyopathy OR ACM OR arrhythmogenic right ventricular cardiomyopathy OR ARVC OR arrhythmogenic right ventricular dysplasia OR ARVD OR ARVD*C) OR (non-compaction OR NCCM OR LVNC OR RVNC))):ti,ab,kw Quality assessment The Newcastle – Ottawa Quality Assessment Scale (NOS) for case-control studies was used for assessment of case-control studies, and the NOS for cohort studies was used for (longitudinal) cohort studies. In case of a study with a mixed case-control design and a cohort study design, the study was assessed with both scales. The quality assessment was performed by two independent observers (K.T. and F.K.) and disagreement was solved by consensus. Newcastle – Ottawa Quality Assessment Scale for case-control studies Selection, Q1: Is the case definition adequate? (1p) A point was awarded if the included relatives were identified through screening of the family of an index patient. 7
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