176 | Chapter 8 CONCLUSION This study showed that inclusion of regional abnormalities in RV function can further refine personalized arrhythmic risk prediction in ARVC. Both regional deformation patterns and longitudinal strain of the RV free wall improved prediction of arrhythmic outcome beyond the ARVC risk calculator. With a two-step approach, the excellent negative predictive value of normal RV deformation could support clinicians considering timing of ICD implantation in patients with intermediate arrhythmic risk. Central illustration ARVC = arrhythmogenic right ventricular cardiomyopathy; RV = right ventricular; RVEF = right ventricular ejection fraction; RVFWLS = right ventricular free wall longitudinal strain; VA = ventricular arrhythmia.
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