180 | Chapter 8 SUPPLEMENTARY MATERIAL Supplemental Table 1. Intra- and inter-observer variability in deformation imaging measurements Utrecht Oslo INTRA_1 INTRA_2 INTER_1_2 INTER GLS ICC + 95%CI 0.95 [0.81;0.98] 0.96 [0.91;0.98] 0.94 [0.89;0.96] 0.92 [0.81;0.97] LVMD ICC + 95%CI 0.96 [0.91;0.99] 0.99 [0.96;0.99] 0.92 [0.86;0.96] 0.87 [0.71;0.95] RVMD ICC + 95%CI 0.87 [0.71;0.95] x 0.84 [0.64;0.93] 0.91 [0.78;0.96] RV patterns difference 3/20 0/20 3/40 2/20 K 0.74 p <0.001 1.00 p <0.001 0.87 p <0.001 0.85 p <0.001 weighted K 0.78 p <0.001 1.00 p <0.001 0.89 p <0.001 0.89 p <0.001 Abbreviations: GLS = global longitudinal strain, ICC = intraclass correlation coefficient, K = kappa statistic, LV = left ventricle, MD = mechanical dispersion, RV = right ventricle. Supplemental Table 2. Complete case analyses without imputation of RVEF and 24-hour PVC count RVEF imputation using MICE multivariable analysis Complete case multivariable analysis Adjusted HR (95% CI) p-value Adjusted HR (95% CI) p-value Risk calculator model + RVFWLS per % worsening 1.07 (1.02 – 1.11) 0.004 1.08 (1.02 – 1.13) 0.004 + RV deformation abnormal 4.45 (1.07 – 18.57) 0.040 3.32 (0.79 – 13.98) 0.102 + LV GLS per % worsening 1.07 (0.98 – 1.18) 0.138 1.06 (0.95 – 1.18) 0.277 Hazard ratios (HR) are adjusted for the calculator-predicted risk. HR are presented with 95% CIs. Abbreviations: LV GLS = left ventricular global longitudinal strain, RV = right ventricular, RVEF = right ventricular ejection fraction, RVFWLS = right ventricular free wall longitudinal strain. 24-hour Holter count imputation using MICE multivariable analysis Complete case multivariable analysis Adjusted HR (95% CI) p-value Adjusted HR (95% CI) p-value Risk calculator model + RVFWLS per % worsening 1.07 (1.02 – 1.11) 0.004 1.07 (1.02 – 1.13) 0.007 + RV deformation abnormal 4.45 (1.07 – 18.57) 0.040 3.72 (0.88 – 15.77) 0.074 + LV GLS per % worsening 1.07 (0.98 – 1.18) 0.138 1.04 (0.93 – 1.17) 0.451 Hazard ratios (HR) are adjusted for the calculator-predicted risk. HR are presented with 95% CIs. Abbreviations: LV GLS = left ventricular global longitudinal strain, RV = right ventricular, RVFWLS = right ventricular free wall longitudinal strain.
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