Arrhythmic Risk Prediction in ARVC | 181 Supplemental Table 3. Baseline characteristics separated by centre All (n=150) Utrecht (n=87) Oslo (n=63) p-value Demographics Age at echocardiography, yrs 41.3 ± 17.1 40.3 ± 16.3 42.7 ± 18.3 0.409 Male 75 (50) 39 (45) 36 (57) 0.186 Probands 51 (34) 25 (29) 26 (41) 0.154 Follow-up duration, yrs 6.3 (3.1 – 9.8) 7.2 (3.8 – 10.3) 4.5 (2.0 – 9.1) 0.042 Genetic status P/LP variant PKP2 DSP DSG2 PLN Multiple Other 129 (86) 99 (66) 3 (2) 5 (3) 18 (12) 1(1) 3 (2) 81 (93) 57 (66) 2 (2) 2 (2) 18 (21) 0 (0) 2 (2) 48 (76) 42 (67) 1 (2) 3 (5) 0 (0) 1 (2) 1 (2) 0.007 Clinical history Any cardiac symptoms 105 (70) 58 (67) 47 (75) 0.386 Recent cardiac syncope 12 (8) 5 (6) 7 (11) 0.373 Clinical phenotype Total TFC score (IQR) 5 (4-6) 5 (4-7) 5 (4-6) 0.227 Age at diagnosis 40.7 ± 16.7 39.6 ± 15.4 42.2 ± 18.3 0.343 ECG TWI in ≥3 precordial leads 57 (38) 30 (35) 27 (43) 0.312 TWI in ≥2 inferior leads 22 (15) 10 (12) 12 (19) 0.244 PVC count 497 (48 – 2322) 555 (126 – 2261) 409 (20 – 3201) 0.597 NSVT 67 (45) 39 (45) 28 (45) 1 CMR RVEF, % 46 ± 10 46 ± 9 45 ± 13 0.830 RVEDVi, ml 109 ± 29 108 ± 26 111 ± 37 0.568 LVEF, % 54 ± 9 53 ± 8 55 ± 9 0.372 LGE 23 (20) 17 (22) 6 (15) 0.465 Traditional echocardiography LVEF, % 55 ± 8 54 ± 8 56 ± 9 0.216 RVFAC, % 39 ± 9 40 ± 9 38 ± 9 0.207 RVOT, mm 35 ± 7 33 ± 6 37 ± 7 <0.001 Echocardiographic deformation imaging LV GLS, % -18.2 ± 3.2 -18.5 ± 3.2 -17.9 ± 3.2 0.224 LVMD, ms 38(31 – 47) 38 (29 – 48) 39 (33 – 47) 0.571 RVFWLS, % -19.5 ± 7.0 -20.4 ± 6.0 -18.3 ± 8.0 0.072 8
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