206 | Chapter 10 Statistical analysis Parametric data were presented as mean ± standard deviation, median [interquartile range] or number (%). Comparisons were performed using a Student’s t-test, Mann-Whitney U test, or Fisher exact test as appropriate. Analyses were performed with SPSS version 24.0 (SPSS Inc., Chicago, Illinois). Intra- and inter-observer variability was expressed by intraclass correlation coefficients (ICC). Two-sided p values <0.05 were considered significant. RESULTS Study population After screening 106 IVF patients from three centers, a total of 72 patients (mean age 39 ± 14 years, 42% female) and 72 age- and sex-matched control subjects (mean age 41 ± 11 years, 42% female) were included (Figure 1). In total, 23 patients were excluded due to CMR unavailability and 11 patients were excluded due to insufficient image quality. An ICD for secondary prevention was implanted in all but one of the IVF patients (99%) (Table 1). Table 1. Baseline characteristics of idiopathic ventricular fibrillation patients Characteristics All (n=72) Age, yrs 39 ± 14 Female, n (%) 30 (42) Circumstances event, n (%) - Rest 43 (60) - Exercise 16 (22) - Asleep 9 (12) - Emotions 4 (6) Genetic testing - DPP6 haplotype 9 (13) Electrocardiogram - Heart rate, bpm 69 ± 13 ICD implantation 71 (99) Values are, n (%), mean ± standard deviation. Abbreviations: bpm = beats per minute, ICD = implantable cardioverter defibrillator. Prevalence of mitral valve disease MAD was commonly measured in the anterior, inferior and anterolateral wall in both IVF patients and healthy controls (Table 2). The inferolateral wall was the only distinctive location for the presence of MAD between IVF patients and controls (7 [11%] vs. 1 [1%], p=0.024). In addition, IVF patients showed a higher prevalence of MVP (5 [8%] vs. 0 [0%], p=0.016). A curling sign of the inferior wall was observed in three IVF patients with MAD and not in controls. One control subject showed MAD in the inferolateral wall of 2 mm, without signs of other mitral valve disease. In seven IVF patients with inferolateral MAD, other mitral valve disease was prevalent; four (57%) also had MVP, of which three females with bi-leaflet MVP, and four patients (57%) showed signs of mitral regurgitation. One patient with MVP did not have inferolateral MAD.
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