Right Ventricular Functional Abnormalities in ARVC | 45 Central illustration. Risk stratification in arrhythmogenic cardiomyopathy (AC) We enrolled 160 arrhythmogenic cardiomyopathy (AC) probands and mutation-positive family members from two large European referral centers, of which 47 had experienced life-threatening ventricular arrhythmia (VA). (top) We performed speckle tracking echocardiography, whereby we classified the subtricuspid deformation patterns from normal to abnormal and assessed RV mechanical dispersion from 6 segments. Both methods were first externally validated and compared to the cohort where the method was developed. (top left) Subsequently, a combined approach was developed, in which a normal deformation pattern (type I) was associated with an excellent negative predictive value (NPV), requiring no further analyses. (bottom left) In patients with an abnormal deformation pattern (type II or III), mechanical dispersion further stratified between intermediate and high arrhythmic risk. (bottom right) 3
RkJQdWJsaXNoZXIy MTk4NDMw