50 | Chapter 3 Supplementary table 1. intra- and inter-observer variability in deformation imaging measurements Utrecht Oslo INTRA_1 INTRA_2 INTER_1_2 INTER GLS ICC + 95%CI 0.95 (0.81;0.98) 0.96 (0.91;0.98) 0.94 (0.89;0.96) 0.92 (0.81;0.97) LVMD ICC + 95%CI 0.96 (0.91;0.99) 0.99 (0.96;0.99) 0.92 (0.86;0.96) 0.87 (0.71;0.95) RVMD ICC + 95%CI 0.87 (0.71;0.95) x 0.84 (0.64;0.93) 0.91 (0.78;0.96) RV patterns difference 3/20 0/20 3/40 2/20 K 0.74 p <0.001 1.00 p <0.001 0.87 p <0.001 0.85 p <0.001 weighted K 0.78 p <0.001 1.00 p <0.001 0.89 p <0.001 0.89 p <0.001 Abbreviations: CI = confidence interval, GLS = global longitudinal strain, ICC = intraclass correlation coefficient, K = kappa statistic, LV = left ventricle, MD = mechanical dispersion, RV = right ventricle Supplementary table 2. Clinical characteristics comparison of patients without and with history of life-threatening arrhythmia at inclusion, separated by center. All (n=160) (n=80) (n=80) No VA (n=113) (n=55) (n=58) VA (n=47) (n=25) (n=22) p-value Age, yrs (n = 160) Oslo (n = 80) Utrecht (n = 80) 40.6 ± 16.8 40.9 ± 16.1 40.4 ± 17.6 38.2 ± 17.4 38.8 ± 16.9 37.7 ± 17.9 46.4 ± 13.9 45.5 ± 13.4 47.5 ± 14.7 0.002 0.06 0.03 Female, n(%) (n = 160) Oslo (n = 80) Utrecht (n = 80) 88 (55) 44 (55) 44 (55) 69 (61) 31 (56) 38 (66) 19 (40) 13 (52) 6 (27) 0.01 0.90 0.002 Probands, n(%) (n = 160) Oslo (n = 80) Utrecht (n = 80) 68 (43) 40 (50) 28 (35) 23 (20) 16 (29) 7 (12) 45 (96) 24 (96) 21 (96) <0.001 <0.001 <0.001 BSA, m2 (n = 158) Oslo (n = 79) Utrecht (n = 79) 1.9 ± 0.2 2.0 ± 0.2 1.9 ± 0.2 1.9 ± 0.2 1.9 ± 0.2 1.8 ± 0.2 2.0 ± 0.2 2.0 ± 0.2 2.0 ± 0.2 <0.001 0.06 0.008 Definite AC, n(%) (n = 160) Oslo (n = 80) Utrecht (n = 80) 97 (61) 47 (59) 50 (63) 57 (50) 29 (53) 28 (48) 40 (85) 18 (72) 22 (100) <0.001 0.11 <0.001 AA med., n(%) (n = 160) Oslo (n = 80) Utrecht (n = 80) 44 (28) 12 (15) 32 (40) 16 (14) 5 (9) 11 (19) 28 (60) 7 (28) 21 (96) <0.001 0.03 <0.001 BB, n(%) (n = 160) Oslo (n = 80) Utrecht (n = 80) 60 (38) 27 (34) 33 (41) 35 (31) 20 (36) 15 (26) 25 (53) 7 (28) 18 (82) 0.008 0.46 <0.001 Mutation, n(%) (n = 159) Oslo (n = 79) Utrecht (n = 80) 139 (87) 59 (75) 80 (100) 103 (92) 45 (83) 58 (100) 36 (77) 14 (56) 22 (100) 0.008 0.009 -
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