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52 | Chapter 3 Supplementary table 3. Electrocardiographic parameter comparison between patients without and with history of life-threatening arrhythmia at inclusion, separated by center. (continued) All (n=160) (n=80) (n=80) No VA (n=113) (n=55) (n=58) VA (n=47) (n=25) (n=22) p-value PVC>500, n(%) (n = 158) Oslo (n = 79) Utrecht (n = 79) 43 (27) 17 (22) 26 (33) 33 (30) 13 (24) 20 (35) 10 (22) 4 (16) 6 (29) 0.32 0.42 0.62 VT major, n(%) (n = 160) Oslo (n = 80) Utrecht (n = 80) 29 (18) 10 (13) 19 (24) 4 (4) 2 (4) 2 (3) 25 (53) 8 (32) 17 (77) <0.001 <0.001 <0.001 VT minor, n(%) (n = 160) Oslo (n = 80) Utrecht (n = 80) 57 (36) 32 (40) 25 (31) 36 (32) 16 (29) 20 (35) 21 (45) 16 (64) 5 (23) 0.12 0.003 0.31 SAECG abn.l, n(%) (n = 75)## Oslo (n = 75) Utrecht (n = 0) 43 (57) 25 (50) 18 (72) 0.07 Values are, n (%), mean ± standard deviation. Abbreviations: HR = heart rate, NSVT = non-sustained ventricular tachycardia, PVC = premature ventricular complex, TAD = terminal activation duration, SAECG = signal averaged electrocardiogram, TWI = T-wave inversion, VA = ventricular arrhythmia, VT = ventricular tachycardia. # Occurence of NSVT was not systematically documented in Utrecht and thus only available for patients from the Oslo cohort. ## SAECG was not routinely performed in Utrecht and thus only available for patients from the Oslo cohort. Supplementary table 4. Cardiac imaging parameter comparison between patients without and with history of life-threatening arrhythmia at inclusion, separated by center. All (n=160) (n=80) (n=80) No VA (n=113) (n=55) (n=58) VA (n=47) (n=25) (n=22) p-value EF, % (n = 160) Oslo (n = 80) Utrecht (n = 80) 56.7 ± 6.7 56.5 ± 6.6 56.9 ± 6.9 57.1 ± 5.8 56.6 ± 6.0 57.7 ± 5.7 55.7 ± 8.5 56.3 ± 7.9 55.1 ± 9.3 0.31 0.89 0.14 GLS, % (n = 159) Oslo (n = 79) Utrecht (n = 80) -18.1 ± 3.4 -18.2 ± 3.3 -18.0 ± 3.5 -18.7 ± 2.8 -18.7 ± 2.4 -18.7 ± 3.2 -16.7 ± 4.2 -17.1 ± 4.6 -16.2 ± 3.7 0.003 0.10 0.003 LVMD, ms (n = 159) Oslo (n = 79) Utrecht (n = 80) 41.2 ± 19.8 39.6 ± 14.0 42.7 ± 24.3 37.4 ± 19.4 35.8 ± 10.9 38.8 ± 24.8 50.2 ± 18.0 47.8 ± 16.5 52.9 ± 19.7 <0.001 0.002 0.02 RVD, mm (n = 160) Oslo (n = 80) Utrecht (n = 80) 40.8 ± 9.5 40.7 ± 8.9 41.0 ± 10.1 37.9 ± 6.5 38.3 ± 4.7 37.5 ± 7.9 47.9 ± 11.5 45.9 ± 13.0 50.1 ± 9.5 <0.001 0.008 <0.001

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