Right Ventricular Functional Abnormalities in ARVC | 53 Supplementary table 4. Cardiac imaging parameter comparison between patients without and with history of life-threatening arrhythmia at inclusion, separated by center. (continued) All (n=160) (n=80) (n=80) No VA (n=113) (n=55) (n=58) VA (n=47) (n=25) (n=22) p-value RVFAC, % (n = 159) Oslo (n = 80) Utrecht (n = 79) 37.9 ± 10.5 38.6 ± 10.2 37.3 ± 10.9 41.5 ± 8.9 41.1 ± 7.6 40.9 ± 9.9 29.3 ± 9.3 30.9 ± 11.0 27.4 ± 6.3 <0.001 <0.001 <0.001 RV deformation pattern I, n(%) Oslo (n = 80) Utrecht (n = 80) 43 (27) 24 (30) 19 (24) 42 (37) 24 (44) 18 (31) 1 (2) 0 (0) 3 (5) <0.001 <0.001 0.01 RV deformation pattern II, n(%) Oslo (n = 80) Utrecht (n = 80) 56 (35) 28 (35) 28 (35) 40 (35) 18 (33) 22 (38) 16 (34) 10 (40) 6 (27) 0.87 0.53 0.37 RV deformation pattern III,n(%) Oslo (n = 80) Utrecht (n = 80) 61 (38) 28 (35) 33 (41) 31 (27) 13 (24) 18 (31) 30 (64) 15 (60) 15 (68) <0.001 0.002 0.003 RVFWSL, % (n = 160) Oslo (n = 80) Utrecht (n = 80) -19.3 ± 7.6 -20.7 ± 7.5 -17.9 ± 7.5 -21.4 ± 6.5 -22.6 ± 6.5 -20.3 ± 6.3 -14.0 ± 7.7 -16.4 ± 7.8 -11.3 ± 6.7 <0.001 <0.001 <0.001 RVMD, ms (n = 160) Oslo (n = 80) Utrecht (n = 80) 36.8 ± 26.3 31.8 ± 20.5 41.8 ± 30.2 29.9 ± 21.1 25.9 ± 15.4 33.6 ± 24.8 53.4 ± 30.0 44.7 ± 24.5 63.3 ± 33.1 <0.001 0.001 <0.001 RVOT, mm (n = 158) Oslo (n = 78) Utrecht (n = 80) 34.5 ± 7.8 35.1 ± 6.7 33.9 ± 8.8 32.2 ± 6.1 33.4 ± 5.4 31.1 ± 6.6 40.2 ± 8.6 39.1 ± 7.7 41.4 ± 9.5 <0.001 0.002 <0.001 TAPSE, mm (n = 159) Oslo (n = 80) Utrecht (n = 79) 20.7 ± 4.4 22.4 ± 4.1 19.0 ± 4.0 21.6 ± 3.6 23.2 ± 3.3 20.1 ± 3.2 18.4 ± 5.3 20.6 ± 5.2 15.8 ± 4.1 <0.001 0.03 <0.001 CMR Oslo Utrecht (n=129) (n=69) (n=60) (n=95) (n=47) (n=48) (n=34) (n=22) (n=12) RVEF, % (n = 99) Oslo (n =41) Utrecht (n = 58) 45.9 ± 13.1 48.4 ± 11.6 44.2 ± 13.9 48.6 ± 12.0 50.1 ± 10.5 47.4 ± 12.7 37.4 ± 13.0 43.6 ± 12.9 30.1 ± 9.0 <0.001 0.07 <0.001 RVEDVi, ml (n = 92) Oslo (n = 38) Utrecht (n = 54) 109.8 ± 40.8 107.8 ± 39.6 111.2 ± 41.9 98.6 ± 31.0 94.7 ± 26.5 101.0 ± 33.5 147.7 ± 47.5 140.0 ± 48.7 156.3 ± 47.1 <0.001 0.01 <0.001 LGE, n (%) (n = 124) Oslo (n = 64) Utrecht (n = 60) 34 (27) 13 (20) 21 (34) 14 (15) 4 (10) 10 (20) 20 (59) 9 (41) 11 (92) <0.001 0.003 <0.001 Values are, n (%), mean ± standard deviation. Abbreviations: CMR = cardiac magnetic resonance, EDVi = end diastolic volume indexed, EF = ejection fraction, FAC = fractional area change, GLS = global longitudinal strain, LGE = late gadolinium enhancement, LS = longitudinal strain, LV = left ventricle, MD = mechanical dispersion, RV = right ventricle, RVD = right ventricular diameter, RVOT = right ventricular outflow tract, TAPSE = tricuspid annular plane systolic excursion. 3
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