TABLE OF CONTENTS Introduction Chapter 1 General Introduction and Thesis Outline 9 Part I. Deformation imaging methods in ARVC Chapter 2 Improving Diagnostic Value of Echocardiography in Arrhythmogenic Right Ventricular Cardiomyopathy Using Deformation Imaging JACC Cardiovasc Imaging. 2021;14(12):2481-2483. 25 Chapter 3 Right Ventricular Functional Abnormalities in Arrhythmogenic Cardiomyopathy: Association With Life-Threatening Ventricular Arrhythmias JACC Cardiovasc Imaging. 2021;14(5):900-910. 31 Part II. Characterizing the disease substrate underlying deformation abnormalities Chapter 4 Electromechanical Substrate Characterization in Arrhythmogenic Cardiomyopathy Using Imaging-Based Patient-Specific Computer Simulations Europace. 2021;23(Suppl1):i153-i160. 59 Chapter 5 Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling Frontiers in Physiology. 2021;12:738926. 79 Chapter 6 Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum J Am Coll Cardiol. 2023;82(9):785-97. 103 Part III. Towards clinical implementation of deformation imaging Chapter 7 Echocardiographic Deformation Imaging for Early Detection of Genetic Cardiomyopathies: A Systematic Review J Am Coll Cardiol. 2022;79(6):594-608. 127 Chapter 8 The Added Value of Abnormal Regional Myocardial Function for Risk Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy Eur Heart J Cardiovasc Imaging. 2023;24(12):1710-1718. 163
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