92 | Chapter 5 Figure 6. Measured and estimated strain of virtual subject (left) and violin plots of estimated parameters (right). The estimated properties are close to the true properties of the virtual patient (black dot) and the heterogeneity is well captured. The best simulation in the sample set was closely related to the virtual patients dataset (Χ2 opt =2.0) . Application: Longitudinal datasets Two subjects with a baseline and two follow-up echocardiograms were included in this study (Table 2). The first subject had a follow-up examination after 4.5 and 9.1 years and the second subject after 5.2 and 7.3 years. Results of these case studies are shown in Figure 7 and Figure 8. Subject 1 developed an abnormal deformation pattern of the basal RV segment at last follow-up which was not seen at baseline. Computer simulations showed homogeneous RV contractility, activation delay, compliance, and work at baseline. In the last follow-up examination, an apex-to-base heterogeneity in compliance and work density was present. Subject 2 showed normal RV deformation patterns at baseline and did not develop clear deformation abnormalities during follow-up. Contractility, activation delay, compliance, and work density were estimated homogeneously at baseline. In the final follow-up, a small apexto-base heterogeneity in compliance was present.
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