Feddo Kirkels

Chapter 1 General Introduction and Thesis Outline	9
Part I. Deformation imaging methods in ARVC	23
Chapter 2 Improving Diagnostic Value of Echocardiography in Arrhythmogenic Right Ventricular Cardiomyopathy Using Deformation Imaging	25
Chapter 3 Right Ventricular Functional Abnormalities in Arrhythmogenic Cardiomyopathy: Association With Life-Threatening Ventricular Arrhythmias	31
Part II. Characterizing the disease substrate underlying deformation abnormalities	57
Chapter 4 Electromechanical Substrate Characterization in Arrhythmogenic Cardiomyopathy Using Imaging-Based Patient-Specific Computer Simulations	59
Chapter 5 Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling	79
Chapter 6 Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum	103
Part III. Towards clinical implementation of deformation imaging	125
Chapter 7 Echocardiographic Deformation Imaging for Early Detection of Genetic Cardiomyopathies: A Systematic Review	127
Chapter 8 The Added Value of Abnormal Regional Myocardial Function for Risk Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy	163
Discussion	185
Chapter 9 General Discussion and Future Perspectives	185
Addendum: Left sided wall stress causing arrhythmia	199
Chapter 10 Prevalence of Mitral Annulus Disjunction and Mitral Valve Prolapse in Patients With Idiopathic Ventricular Fibrillation	201
Appendices	220
Nederlandstalige samenvatting	222
List of publications	226
Dankwoord/Acknowledgements	228
Curriculum Vitae	234

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